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. 2021 Jun 25;38(3):498-506.
doi: 10.7507/1001-5515.202010037.

[Research on characteristics of brain functional network in stroke patients during convalescent period under transcranial direct current stimulation]

[Article in Chinese]
Mengmeng Liu  1   2 , Guizhi Xu  1   2 , Hongli Yu  1   2 , Chunfang Wang  3 , Changcheng Sun  3 , Lei Guo  1   2
Affiliations

[Research on characteristics of brain functional network in stroke patients during convalescent period under transcranial direct current stimulation]

[Article in Chinese]
Mengmeng Liu et al. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. .

Abstract
in English, Chinese

Transcranial direct current stimulation (tDCS) is an emerging non-invasive brain stimulation technique. However, the rehabilitation effect of tDCS on stroke disease is unclear. In this paper, based on electroencephalogram (EEG) and complex network analysis methods, the effect of tDCS on brain function network of stroke patients during rehabilitation was investigated. The resting state EEG signals of 31 stroke rehabilitation patients were collected and divided into stimulation group (16 cases) and control group (15 cases). The Pearson correlation coefficients were calculated between the channels, brain functional network of two groups were constructed before and after stimulation, and five characteristic parameters were analyzed and compared such as node degree, clustering coefficient, characteristic path length, global efficiency, and small world attribute. The results showed that node degree, clustering coefficient, global efficiency, and small world attributes of brain functional network in the tDCS group were significantly increased, characteristic path length was significantly reduced, and the difference was statistically significant ( P < 0.05). It indicates that tDCS can improve the brain function network of stroke patients in rehabilitation period, and may provide theory and experimental basis for the application of tDCS in stroke rehabilitation treatment.

经颅直流电刺激（tDCS）作为一种新兴的非侵入性脑刺激技术，对脑卒中疾病的康复作用目前尚未明确。本文结合脑电图（EEG）与复杂网络分析方法研究了 tDCS 对脑卒中患者康复期脑功能网络的影响。试验采集了 31 名脑卒中患者康复期的静息态 EEG 信号，其中 16 名患者作为试验组施加真刺激，15 名患者作为对照组施加伪刺激。利用皮尔逊相关系数法计算 EEG 信号之间的相关系数，并构建了两组受试者 tDCS 刺激前、后的脑功能网络，分析对比了不同状态下脑功能网络的节点度、聚类系数、特征路径长度、全局效率和“小世界”属性 5 个特征参数。结果发现，tDCS 真刺激后脑卒中患者脑功能网络的节点度、聚类系数、全局效率和“小世界”属性显著升高，特征路径长度显著降低，且差异具有统计学意义（ P < 0.05）。该结果表明 tDCS 能够改善脑卒中患者康复期的脑功能网络，本研究可为 tDCS 应用于脑卒中康复治疗提供理论和试验依据。.

Keywords: brain function network; electroencephalogram; stroke; transcranial direct current stimulation.

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Conflict of interest statement

利益冲突声明：本文全体作者均声明不存在利益冲突。

Figures

图 1
图 1
Flow chart of experiment 试验流程图
图 2
图 2
The comparison of brain network connections before and after stimulation 刺激前、后脑网络连接对比结果
图 3
图 3
The comparison of node degree in brain network before and after stimulation 刺激前、后脑网络的节点度对比
图 4
图 4
Node degree of EEG information diagram before and after stimulation 刺激前、后节点度 EEG 信息图
图 5
图 5
The comparison of clustering coefficient in brain network before and after stimulation 刺激前、后脑网络的聚类系数对比
图 6
图 6
Clustering coefficient of EEG information diagram before and after stimulation 刺激前、后聚类系数 EEG 信息图
图 7
图 7
The comparison of average characteristic path length in brain network before and after stimulation 刺激前、后脑网络的平均特征路径长度对比结果
图 8
图 8
The comparison of average global efficiency in brain network before and after stimulation 刺激前、后脑网络的平均全局效率对比结果
图 9
图 9
The comparison of small world attribute in brain network before and after stimulation 刺激前、后脑网络的“小世界”属性对比结果
See this image and copyright information in PMC

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