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. 2021 Jul 6;10(13):e020039.
doi: 10.1161/JAHA.120.020039. Epub 2021 Jun 26.

Cardiac Biomarker Kinetics and Their Association With Magnetic Resonance Measures of Cardiomyocyte Integrity Following a Marathon Run: Implications for Postexercise Biomarker Testing

Vincent L Aengevaeren  1   2 , Roland R J van Kimmenade  2 , Jordi Ordóñez-Llanos  3 , Álvaro García-Osuna  3 , Thomas E Kaier  4 , Michael Marber  4 , Martijn Froeling  5 , Sandra van den Berg-Faay  6 , Melissa T Hooijmans  7 , Jithsa R Monte  6 , Maria T E Hopman  1 , Gustav J Strijkers  7 , Aart J Nederveen  6 , Adrianus J Bakermans  6 , Thijs M H Eijsvogels  1
Affiliations

Cardiac Biomarker Kinetics and Their Association With Magnetic Resonance Measures of Cardiomyocyte Integrity Following a Marathon Run: Implications for Postexercise Biomarker Testing

Vincent L Aengevaeren et al. J Am Heart Assoc. .
No abstract available

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Conflict of interest statement

EMD Merck Millipore (Hayward, CA) was contracted to undertake the analyses of cardiac myosin–binding protein C on a fee‐for‐service basis and holds no commercial interest. Dr Marber is named as an inventor on a patent held by King's College London for the detection of cardiac myosin–binding protein C as a biomarker of myocardial injury. The remaining authors have no disclosures to report.

Figures

Figure 1
Figure 1. Cardiac biomarker kinetics following a marathon run.
cTnI measured using a conventional assay (upper reference limit [URL], 40 ng/L; limit of detection [LOD], 6 ng/L; A), SMC‐cTnI (URL, 8.97 ng/L; LOD, 0.12 ng/L; B), hs‐cTnT (URL, 14 ng/L; LOD, 3 ng/L; C), cMyC (URL, 87 ng/L; LOD, 0.4 ng/L; D), sST2 (standard analysis cut point, 35 µg/L; LOD, 1.8 µg/L; E), and BNP (clinical cut point, 35 pg/mL; LOD, 2 pg/mL; F) measured at 6 time points surrounding a marathon run. Data for each individual participant are shown in gray, with group median values (n = 11) indicated by the red lines. Horizontal dashed lines indicate the URLs and/or clinical cut points. BNP indicates B‐type natriuretic peptide; cMyC, cardiac myosin–binding protein C; cTnI, cardiac troponin I; hs‐cTnT, high‐sensitivity troponin T; MRI, magnetic resonance imaging; SMC, single‐molecule counting assay; and sST2, soluble suppression of tumorigenicity 2.
See this image and copyright information in PMC

References

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