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. 2021 Jul;33(5):824-831.
doi: 10.1111/jerd.12744. Epub 2021 Jun 28.

Effects of a reduced in-office bleaching protocol with 37.5% hydrogen peroxide on effectiveness and tooth sensitivity: A double-blind randomized clinical trial

Sônia Saeger Meireles  1 , Mariana Evangelista Santos  2 , Ísis Moreira Cardoso Lustosa  3 , Eva Lis Lopes Leite  1
Affiliations

Effects of a reduced in-office bleaching protocol with 37.5% hydrogen peroxide on effectiveness and tooth sensitivity: A double-blind randomized clinical trial

Sônia Saeger Meireles et al. J Esthet Restor Dent. 2021 Jul.

Abstract

Objective: This randomized clinical trial evaluated the effectiveness and tooth sensitivity (TS) of 37.5% hydrogen peroxide (37.5HP) in-office bleaching with reduced protocol.

Materials and methods: Forty participants with shade mean C2 or darker for the six maxillary anterior teeth were randomly allocated into two treatment groups (n = 20): two (37.5HP2) or three (37.5HP3) 8 min applications/clinical session. Three clinical sessions were performed with a 1 week interval. Color evaluations were done with a spectrophotometer at baseline and 1 week post-bleaching. TS was measured during and up to 48 h after bleaching using a five-point numeric rating scale. Color change was evaluated by Student's t-test for independent samples. The absolute risk and intensity of TS were analyzed by Fisher's and Mann-Whitney/Friedman tests (p < 0.05).

Result: Both treatment groups resulted in a significant tooth whitening 1 week post-bleaching (p < 0.001). There were no significant differences between 37.5HP2 and 37.5HP3 for ΔE*ab , ΔE00 and ∆WID . Also, there were not differences between groups regarding high absolute risk (p = 1.0) and low intensity of TS at all time assessments (p > 0.7).

Conclusions: The in-office bleaching with two 37.5% HP applications produced the same whitening degree, risk and intensity of TS to that performed with three gel applications.

Clinical significance: Clinicians should opt to use a neutral 37.5% HP in-office bleaching gel for two 8 min applications/clinical session because produces the same whitening effectiveness, risk and low intensity of TS as the protocol proposed by manufacturer (three 8 min applications).

Keywords: dentin sensitivity; hydrogen peroxide; randomized controlled trial; tooth bleaching.

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References

REFERENCES

    1. Kothari S, Jum'ah AA, Gray AR, Lyons K, et al. A randomized clinical trial investigating three vital tooth bleaching protocols and associated efficacy, effectiveness and participants' satisfaction. J Dent. 2020;95:103322.
    1. Loguercio AD, Servat F, Stanislawczuk R, et al. Effect of acidity of in-office bleaching gels on tooth sensitivity and whitening: a two-center double-blind randomized clinical trial. Clin Oral Investig. 2017;21(9):2811-2818.
    1. Kothari S, Gray AR, Lyons K, Tan XW, Brunton PA. Vital bleaching and oral-health-related quality of life in adults: a systematic review and meta-analysis. J Dent. 2019;84:22-29.
    1. Meireles SS, Goettems ML, Dantas RV, Bona ÁD, et al. Changes in oral health related quality of life after dental bleaching in a double-blind randomized clinical trial. J Dent. 2014;42(2):114-121.
    1. Cosmetic Dentistry State of the Industry Survey, (2019) (Last accessed August 31, 2020), https://aacd.realmagnet.land/SOI-survey-2019

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