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Review
. 2021 Dec;18(6):917-930.
doi: 10.1007/s13770-021-00356-x. Epub 2021 Jun 28.

Research Models of the Nanoparticle-Mediated Drug Delivery across the Blood-Brain Barrier

Quan-You Li  1 , Jung-Hwan Lee  2   3   4   5 , Hae-Won Kim  6   7   8   9 , Guang-Zhen Jin  10   11   12
Affiliations
Review

Research Models of the Nanoparticle-Mediated Drug Delivery across the Blood-Brain Barrier

Quan-You Li et al. Tissue Eng Regen Med. 2021 Dec.

Abstract

Brain diseases and damages come in many forms such as neurodegenerative diseases, tumors, and stroke. Millions of people currently suffer from neurological diseases worldwide. While Challenges of current diagnosis and treatment for neurological diseases are the drug delivery to the central nervous system. The Blood-Brain Barrier (BBB) limits the drug from reaching the targeted site thus showing poor effects. Nanoparticles that have advantage of the assembly at the nanoscale of available biomaterials can provide a delivery platform with potential to raising brain levels of either imaging therapeutic drugs or imaging. Therefore, successful modeling of the BBB is another crucial factor for the development of nanodrugs. In this review, we analyze the in vitro and in vivo findings achieved in various models, and outlook future development of nanodrugs for the successful treatment of brain diseases and damages.

Keywords: Blood brain barrier; In vitro models; In vivo models; Nanoparticles; Neurological diseases.

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1
Fig. 1
In vitro models of blood brain barrier (BBB); A static and B dynamic co-culture
Fig. 2
Fig. 2
The delivery of NPs-mediated drug into the brain of animal models of neurological diseases by crossing the BBB
See this image and copyright information in PMC

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