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Comment
. 2021 Oct;174(10):1468-1469.
doi: 10.7326/M21-2680. Epub 2021 Jun 29.

Thrombosis After Vaccination With Messenger RNA-1273: Is This Vaccine-Induced Thrombosis and Thrombocytopenia or Thrombosis With Thrombocytopenia Syndrome?

Allyson M Pishko  1 , Adam Cuker  1
Affiliations
Comment

Thrombosis After Vaccination With Messenger RNA-1273: Is This Vaccine-Induced Thrombosis and Thrombocytopenia or Thrombosis With Thrombocytopenia Syndrome?

Allyson M Pishko et al. Ann Intern Med. 2021 Oct.

Abstract

In their article, Sangli and colleagues described catastrophic thrombosis after the second dose of the SARS-CoV-2 messenger RNA–1273 vaccine from Moderna. The editorialists discuss vaccine-induced thrombosis and thrombocytopenia and thrombosis with thrombocytopenia syndrome and why this case cannot be definitively attributed to the vaccine. They also note that the remarkable speed with which clinicians and scientists have recognized this rare entity and developed evidence-based diagnosis and treatment guidelines should bolster public confidence in postlicensure vaccine safety monitoring.

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Conflict of interest statement

Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M21-2680.

Comment on

  • Thrombosis With Thrombocytopenia After the Messenger RNA-1273 Vaccine.
    Sangli S, Virani A, Cheronis N, Vannatter B, Minich C, Noronha S, Bhagavatula R, Speredelozzi D, Sareen M, Kaplan RB. Sangli S, et al. Ann Intern Med. 2021 Oct;174(10):1480-1482. doi: 10.7326/L21-0244. Epub 2021 Jun 29. Ann Intern Med. 2021. PMID: 34181446 Free PMC article. No abstract available.

References

    1. Cines DB , Bussel JB . SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia [Editorial]. N Engl J Med. 2021;384:2254-2256. [PMID: ] doi: 10.1056/NEJMe2106315 - DOI - PMC - PubMed
    1. Schultz NH , Sørvoll IH , Michelsen AE , et al. Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination. N Engl J Med. 2021;384:2124-2130. [PMID: ] doi: 10.1056/NEJMoa2104882 - DOI - PMC - PubMed
    1. Shimabukuro T. Update: thrombosis with thrombocytopenia syndrome (TTS) following COVID-19 vaccination. Advisory Committee on Immunization Practices (ACIP); 2021. Accessed at www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-05-12/07-COVID-... on 17 June 2021.
    1. Sangli S, Virani A, Cheronis N, et al. Thrombosis with thrombocytopenia after the messenger RNA–1273 vaccine. Ann Intern Med. 29 June 2021. [Epub ahead of print]. doi:10.7326/L21-0244 - PMC - PubMed
    1. Brighton Collaboration. Interim case definition of thrombosis with thrombocytopenia syndrome (TTS). Accessed at https://brightoncollaboration.us/thrombosis-with-thrombocytopenia-syndro... on 14 June 2021.