Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Aug:83:377-383.
doi: 10.1016/j.semcancer.2021.06.022. Epub 2021 Jun 26.

Epigenetic Regulation of Cancer Immune Cells

Affiliations
Review

Epigenetic Regulation of Cancer Immune Cells

Diego M Avella Patino et al. Semin Cancer Biol. 2022 Aug.

Abstract

The epigenetic regulation of immune response involves reversible and heritable changes that do not alter the DNA sequence. Though there have been extensive studies accomplished relating to epigenetic changes in cancer cells, recent focus has been shifted on epigenetic-mediated changes in the immune cells including T cells, Macrophages, Natural Killer cells and anti-tumor immune responses. This review compiles the most relevant and recent literature related to the role of epigenetic mechanisms including DNA methylation and histone modifications in immune cells of wide range of cancers. We also include recent research with respect to role of the most relevant transcription factors that epigenetically control the anti-tumor immune response. Finally, a statement of future direction that promises to look forward for strategies to improve immunotherapy in cancer.

Keywords: DNA methylation; Epigenetics; Histone modification and antitumor immunity; Tumor infiltrated immune cells.

PubMed Disclaimer

Publication types

LinkOut - more resources