Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Oct;9(10):3841-3843.e1.
doi: 10.1016/j.jaip.2021.05.042. Epub 2021 Jun 25.

Expression of MRGPRX2 in skin mast cells of patients with maculopapular cutaneous mastocytosis

Vishwa Deepak  1 , Hirsh D Komarow  2 , Abdulaziz A Alblaihess  3 , Melody C Carter  2 , Dean D Metcalfe  2 , Hydar Ali  4
Affiliations

Expression of MRGPRX2 in skin mast cells of patients with maculopapular cutaneous mastocytosis

Vishwa Deepak et al. J Allergy Clin Immunol Pract. 2021 Oct.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Statement: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.. Expression of Tryptase and MRGPRX2 in MPCM.
Relative mRNA expression for Tryptase (top left panel), and MRGPRX2 (bottom left panel). Immunofluorescence staining of MRGPRX2 and Tryptase (right panel). Scale bar=50μm. MRGPRX2 (red), Tryptase (green) and DAPI (blue). Data are mean ± SD. Unpaired t test *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001 UP vs control.
See this image and copyright information in PMC

Comment in

  • MRGPRX2: A novel biomarker in mastocytosis?
    Konantz M, Merkel T, Meyer SC, Hartmann K. Konantz M, et al. J Allergy Clin Immunol Pract. 2023 Feb;11(2):669-671. doi: 10.1016/j.jaip.2022.10.053. J Allergy Clin Immunol Pract. 2023. PMID: 36759088 No abstract available.

References

    1. Fujisawa D, Kashiwakura J, Kita H, Kikukawa Y, Fujitani Y, Sasaki-Sakamoto T, et al. Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria. J Allergy Clin Immunol 2014; 134:622–33 e9. - PubMed
    1. Plum T, Wang X, Rettel M, Krijgsveld J, Feyerabend TB, Rodewald HR. Human Mast Cell Proteome Reveals Unique Lineage, Putative Functions, and Structural Basis for Cell Ablation. Immunity 2020; 52:404–16 e5. - PubMed
    1. Roy S, Chompunud Na Ayudhya C, Thapaliya M, Deepak V, and Ali H. Multifaceted MRGPRX2: New Insight into the Role of Mast Cells in Health and Disease. Journal of Allergy and Clinical Immunology 2021. - PMC - PubMed
    1. Metcalfe DD, Mekori YA. Pathogenesis and Pathology of Mastocytosis. Annu Rev Pathol 2017; 12:487–514. - PubMed
    1. Giavina-Bianchi P, Goncalves DG, Zanandrea A, Borges de Castro R, Garro LS, Kalil J, et al. Anaphylaxis to quinolones in mastocytosis: Hypothesis on the mechanism. J Allergy Clin Immunol Pract 2019; 7:2089–90. - PubMed

Publication types