Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul-Aug;35(4):2041-2046.
doi: 10.21873/invivo.12473.

Significant Association of Cyclin D1 Promoter Genotypes With Asthma Susceptibility in Taiwan

Chia-Hsiang Li  1   2 , Kuo-Liang Chiu  3   4 , Te-Chun Hsia  2   5 , Te-Chun Shen  2   5 , Li-Hsiou Chen  1   3 , Chien-Chih Yu  5   6 , Mei-Chin Mong  7 , Wen-Shin Chang  1   5 , Chia-Wen Tsai  1   5 , DA-Tian Bau  8   5   9
Affiliations

Significant Association of Cyclin D1 Promoter Genotypes With Asthma Susceptibility in Taiwan

Chia-Hsiang Li et al. In Vivo. 2021 Jul-Aug.

Abstract

Background/aim: The molecular mechanisms underlying the association between cell cycle and asthma are poorly understood, and cyclin D1 (CCND1) is found to be upregulated in asthma airway smooth muscle. We investigated whether the most frequently examined functional variants in CCND1 determine asthma susceptibility.

Materials and methods: We genotyped 651 participants for single-nucleotide polymorphisms (SNPs) at rs9344 and rs678653 on CCND1 and assessed the association of these SNPs with asthma risk.

Results: Significant differences were found in the distributions of genotypic (p=0.0064) and allelic (p=0.0021) frequencies of CCND1 rs9344. In addition, AG or GG carriers had 0.63- or 0.48-fold adjusted odds ratios for asthma risk (95%confidence intervals=0.48-0.92 and 0.22-0.78, respectively) than those who carried the AA wildtype.

Conclusion: Our results suggest that cell cycle regulation may play a role in asthma initiation and development, and the CCND1 rs9344 genotype may serve as an early detection marker for asthma.

Keywords: Asthma; CCND1; Taiwan; cyclin D1; genotype; polymorphism.

PubMed Disclaimer

Conflict of interest statement

The Authors declare no conflicts of interest in relation to this study.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mattiuzzi C, Lippi G. Worldwide asthma epidemiology: insights from the Global Health Data Exchange database. Int Forum Allergy Rhinol. 2020;10(1):75–80. doi: 10.1002/alr.22464. - DOI - PubMed
    1. Duffy DL, Martin NG, Battistutta D, Hopper JL, Mathews JD. Genetics of asthma and hay fever in Australian twins. Am Rev Respir Dis. 1990;142(6 Pt 1):1351–1358. doi: 10.1164/ajrccm/142.6_Pt_1.1351. - DOI - PubMed
    1. Edfors-Lubs ML. Allergy in 7000 twin pairs. Acta Allergol. 1971;26(4):249–285. doi: 10.1111/j.1398-9995.1971.tb01300.x. - DOI - PubMed
    1. Strina A, Barreto ML, Cooper PJ, Rodrigues LC. Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review. Emerg Themes Epidemiol. 2014;11:5. doi: 10.1186/1742-7622-11-5. - DOI - PMC - PubMed
    1. Temesi G, Virág V, Hadadi E, Ungvári I, Fodor LE, Bikov A, Nagy A, Gálffy G, Tamási L, Horváth I, Kiss A, Hullám G, Gézsi A, Sárközy P, Antal P, Buzás E, Szalai C. Novel genes in human asthma based on a mouse model of allergic airway inflammation and human investigations. Allergy Asthma Immunol Res. 2014;6(6):496–503. doi: 10.4168/aair.2014.6.6.496. - DOI - PMC - PubMed