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. 2021 Jul-Aug;35(4):2349-2355.
doi: 10.21873/invivo.12511.

Role of the Prognostic Nutritional Index in Patients With Soft-tissue Sarcoma

Yumi Matsuyama  1 , Tomoki Nakamura  2 , Keisuke Yoshida  1 , Koichi Nakamura  1 , Tomohito Hagi  1 , Kunihiro Asanuma  1 , Akihiro Sudo  1
Affiliations

Role of the Prognostic Nutritional Index in Patients With Soft-tissue Sarcoma

Yumi Matsuyama et al. In Vivo. 2021 Jul-Aug.

Abstract

Background: This study aimed to determine whether the prognostic nutritional index (PNI) can predict the prognosis in patients with soft-tissue sarcoma (STS) before treatment and to examine whether there is an association between PNI values and clinical characteristics.

Patients and methods: The data on 100 patients with primary STS were retrospectively reviewed. The cohort included 55 men and 45 women, with a mean age of 64 years. The mean follow-up duration was 41.7 months.

Results: The median PNI was 51.35. The PNI was significantly inversely associated with tumor size, tumor grade, and age. We found that the PNI was a significant prognostic marker for disease-specific and event-free survival using univariate and multivariate analyses. Patients with a low PNI had poorer disease-specific and event-free survival than those with a high PNI.

Conclusion: These results suggest that the PNI can be used as a prognostic marker in patients with STS.

Keywords: Prognostic nutritional index; soft tissue sarcoma; survival..

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Conflict of interest statement

There were no conflicts of interest in this study.

Figures

Figure 1
Figure 1. Kaplan-Meier curve showing the disease-specific survival for 100 patients with soft-tissue sarcoma according to prognostic nutritional index (PNI) using a cut-off of 51.35.
Figure 2
Figure 2. Kaplan-Meier curve showing the disease-specific survival for 74 patients with soft-tissue sarcoma, after exclusion of those with welldifferentiated liposarcoma, according to prognostic nutritional index (PNI) using a cut-off of 51.35.
Figure 3
Figure 3. Kaplan-Meier curve showing the event-free survival for 100 patients with soft-tissue sarcoma according to prognostic nutritional index (PNI) using a cut-off of 51.35.
Figure 4
Figure 4. Kaplan-Meier curve showing the event-free survival for 74 patients with soft-tissue sarcoma, after exclusion of those with welldifferentiated liposarcoma, according to prognostic nutritional index (PNI) using a cut-off of 51.35.
See this image and copyright information in PMC

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