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Review
. 1999 Jul 12;38(13-14):1882-1892.
doi: 10.1002/(SICI)1521-3773(19990712)38:13/14<1882::AID-ANIE1882>3.0.CO;2-V.

Nitric Oxide: A Unique Endogenous Signaling Molecule in Vascular Biology (Nobel Lecture)

Louis J Ignarro  1
Affiliations
Review

Nitric Oxide: A Unique Endogenous Signaling Molecule in Vascular Biology (Nobel Lecture)

Louis J Ignarro. Angew Chem Int Ed Engl. .

Abstract

"Endothelium-derived relaxing factor (EDRF) must be nitric oxide." Although there was much experimental evidence that effects on or actions of EDRF were identical to those of nitric oxide, proposing this hypothesis certainly meant going out on a limb. However, once this discovery was made increased investigation indicated the physiological significance of nitric oxide in vascular biology.

Keywords: Enzymes; Neurotransmitters; Nitric oxide; Nobel lecture; Signal transduction.

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