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Observational Study
. 2021 Oct 15;58(10):955-958.
doi: 10.1007/s13312-021-2330-3. Epub 2021 Jun 28.

Clinical Spectrum of Children With Multisystem Inflammatory Syndrome Associated With SARS-CoV-2 Infection

Jolly Chandran  1 , Ebor Jacob James  1 , Valsan P Verghese  2 , T Sathish Kumar  3 , E Kala Ranjini Sundaravalli  1 , Siva Vyasam  1
Affiliations
Observational Study

Clinical Spectrum of Children With Multisystem Inflammatory Syndrome Associated With SARS-CoV-2 Infection

Jolly Chandran et al. Indian Pediatr. .

Abstract

Objectives: To compare the clinical profile, treatment, and outcomes of PCR-positive and PCR-negative antibody-positive critically ill children with multisystem inflammatory syndrome (MIS-C).

Methods: This retrospective observational study was done at a tertiary care coronavirus disease 19 (COVID-19) pediatric intensive care unit in India. The baseline characteristics, clinical profile, treatment, and outcomes in seventeen critically ill children diagnosed with MIS-C were analyzed from 1 July to 31 October, 2020.

Results: Sixteen out of 17 children presented with hypotensive shock and respiratory distress. Mean (SD) age of PCR-negative antibody-positive and PCR-positive children was 11 (4.4) and 5 (3.7) years, respectively (P=0.007). The former group had significantly higher mean (SD) D-dimer levels [16,651 (14859) ng/mL vs 3082 (2591) ng/mL; P=0.02]. All received intensive care management and steroid therapy; 7 children received intravenous immunoglobulin. 14 children survived and 3 died.

Conclusions: The outcome of children with MIS-C was good if recognized early and received intensive care.

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References

    1. Patnaik S, Behera JR, Nayak MK, et al. COVID-19 in children: Present and future perspective, an interim review. J Child Science. 2020;10:53–62. doi: 10.1055/s-0040-1714113. - DOI
    1. Qiu H, Wu J, Hong L, et al. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: An observational cohort study. Lancet. 2020;20:689–96. doi: 10.1016/S1473-3099(20)30198-5. - DOI - PMC - PubMed
    1. Riphagen S, Gomez X, Gonzalez-Martinez C, et al. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;395:1607–8. doi: 10.1016/S0140-6736(20)31094-1. - DOI - PMC - PubMed
    1. World Health Organization. Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19. Scientific Brief 15 May 2020. Accessed on January 14, 2021. Available from: https://www.who.int/news-room/commentaries/detail/multisystem-inflammato...
    1. World Health Organization. Clinical Management of COVID-19. Interim Guidance 27 May 2020. Accessed on January 14, 2021. Available from https://apps.who.int/iris/bitstream/handle/10665/332196/WHO-2019-nCoV-cl...

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