Enhanced hippocampal theta rhythmicity and emergence of eta oscillation in virtual reality

Karen Safaryan¹, Mayank R Mehta^{2

3

4

5}

Affiliations

¹ Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, CA, USA. safaryan@ucla.edu.
² Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, CA, USA. mayankmehta@ucla.edu.
³ W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA. mayankmehta@ucla.edu.
⁴ Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA. mayankmehta@ucla.edu.
⁵ Departments of Neurology and Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA. mayankmehta@ucla.edu.

PMID: 34183867
DOI: 10.1038/s41593-021-00871-z

Free article

Enhanced hippocampal theta rhythmicity and emergence of eta oscillation in virtual reality

Karen Safaryan et al. Nat Neurosci. 2021 Aug.

Free article

. 2021 Aug;24(8):1065-1070.

doi: 10.1038/s41593-021-00871-z. Epub 2021 Jun 28.

Authors

Karen Safaryan¹, Mayank R Mehta^{2

3

4

5}

Affiliations

¹ Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, CA, USA. safaryan@ucla.edu.
² Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, CA, USA. mayankmehta@ucla.edu.
³ W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA. mayankmehta@ucla.edu.
⁴ Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, USA. mayankmehta@ucla.edu.
⁵ Departments of Neurology and Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA. mayankmehta@ucla.edu.

PMID: 34183867
DOI: 10.1038/s41593-021-00871-z

Abstract

Hippocampal theta rhythm is a therapeutic target because of its vital role in neuroplasticity, learning and memory. Curiously, theta differs across species. Here we show that theta rhythmicity is greatly amplified when rats run in virtual reality. A novel eta rhythm emerged in the CA1 cell layer, primarily in interneurons. Thus, multisensory experience governs hippocampal rhythms. Virtual reality can be used to boost or control brain rhythms and to alter neural dynamics, wiring and plasticity.

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References

1. Ravassard, P. et al. Multisensory control of hippocampal spatiotemporal selectivity. Science 340, 1342–1346 (2013). - DOI
1. Kropff, E., Carmichael, J. E., Moser, E. I. & Moser, M. B. Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats. Neuron 109, 1029–1039 (2021). - DOI
1. Buzsáki, G. Hippocampal sharp waves: their origin and significance. Brain Res. 398, 242–252 (1986). - DOI
1. Winson, J. Loss of hippocampal theta rhythm results in spatial memory deficit in the rat. Science 201, 160–163 (1978). - DOI
1. Fuhrmann, F. et al. Locomotion, theta oscillations, and the speed-correlated firing of hippocampal neurons are controlled by a medial septal glutamatergic circuit. Neuron 86, 1253–1264 (2015). - DOI

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Enhanced hippocampal theta rhythmicity and emergence of eta oscillation in virtual reality

Affiliations

Enhanced hippocampal theta rhythmicity and emergence of eta oscillation in virtual reality

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Miscellaneous