Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May 7;8(6):ofab233.
doi: 10.1093/ofid/ofab233. eCollection 2021 Jun.

In-Hospital 30-Day Survival Among Young Adults With Coronavirus Disease 2019: A Cohort Study

Safiya Richardson  1   2 , Jordan Gitlin  2 , Zachary Kozel  2 , Sera Levy  1 , Husneara Rahman  3 , Jamie S Hirsch  1   2   4 , Thomas McGinn  1   2 , Michael A Diefenbach  1   2
Affiliations

In-Hospital 30-Day Survival Among Young Adults With Coronavirus Disease 2019: A Cohort Study

Safiya Richardson et al. Open Forum Infect Dis. .

Abstract

Background: Our objective was to characterize young adult patients hospitalized with coronavirus disease 2019 (COVID-19) and identify predictors of survival at 30 days.

Methods: This retrospective cohort study took place at 12 acute care hospitals in the New York City area. Patients aged 18-39 hospitalized with confirmed COVID-19 between March 1 and April 27, 2020 were included in the study. Demographic, clinical, and outcome data were extracted from electronic health record reports.

Results: A total of 1013 patients were included in the study (median age, 33 years; interquartile range [IQR], 28-36; 52% female). At the study end point, 940 (92.8%) patients were discharged alive, 18 (1.8%) remained hospitalized, 5 (0.5%) were transferred to another acute care facility, and 50 (4.9%) died. The most common comorbidities in hospitalized young adult patients were obesity (51.2%), diabetes mellitus (14.8%), and hypertension (13%). Multivariable analysis revealed that obesity (adjusted hazard ratio [aHR], 2.71; 95% confidence interval [CI], 1.28-5.73; P = .002) and Charlson comorbidity index score (aHR, 1.20; 95% CI, 1.07-1.35; P = .002) were independent predictors of in-hospital 30-day mortality.

Conclusions: Obesity was identified as the strongest negative predictor of 30-day in-hospital survival in young adults with COVID-19.

Keywords: coronavirus disease 2019 (COVID-19); mortality; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); young adults.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Unadjusted Kaplan-Meier curve for survival by obesity status.
Figure 2.
Figure 2.
Forest plot: in-hospital 30-day mortality. BMI, body mass index; HR, hazard ratio.
See this image and copyright information in PMC

References

    1. World Health Organization. Pneumonia of unknown cause – China. Available at: www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/. Accessed 12 June 2020.
    1. World Health Organization. Naming the coronavirus disease (COVID-19) and the virus that causes it. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technica.... Accessed .
    1. Livingston E, Bucher KJJ. Cornavirus disease 2019 (COVID-19) in Italy. JAMA 2020; 323:1335. - PubMed
    1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese center for disease control and prevention. JAMA 2020; 323:1239–42. - PubMed
    1. Centers for Disease Control and Prevention. Severe outcomes among patients with coronavirus disease 2019 (COVID-19) - United States, February 12 - March 16, 2020. MMWR Morb Mortal Wkly Rep 2020; doi: 10.15585/mmwr.mm6912e2. - DOI - PMC - PubMed