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Review
. 2021 Mar 10;8(3):340-354.
doi: 10.3934/Neuroscience.2021018. eCollection 2021.

Neuro-dermatological association between psoriasis and depression: an immune-mediated inflammatory process validating skin-brain axis theory

Shahzaib Maqbool  1 , Arham Ihtesham  1 , Muhammad Nadeem Langove  1 , Sara Jamal  2 , Tabdar Jamal  3 , Hafiz Abu Safian  1
Affiliations
Review

Neuro-dermatological association between psoriasis and depression: an immune-mediated inflammatory process validating skin-brain axis theory

Shahzaib Maqbool et al. AIMS Neurosci. .

Abstract

Objective: Our study's motive was to recognize various immune-mediated inflammatory processes involved in the pathogenesis of depression and psoriasis and interlink between them based on inflammatory mediators.

Methods: A careful and comprehensive literature search was done through various databases like PubMed, Google Scholar, and EBSCO. A total of 56 studies were included in our study after careful screening.

Results: The immune-mediated inflammatory process was significantly associated with the pathogenesis of both depression and psoriasis. Most of the inflammatory markers involved in Psoriasis (TNF-α, IL-2, IL-6, IL-23, IL-1β, IL-10), and increased serotonin transporters (5-HTT) were also found in the pathogenesis of depression, showing the immune-inflammatory linkage between psoriasis and major depression. Based on immune chemistry, the levels of CD2+, CD4+, CD8+ T-lymphocytes were also found to be raised in both depression and psoriasis, validating their relationship. Hyperactivity of HPA-axis was also found another interlink between them along with reduced melatonin amount.

Conclusions: According to various studies, the neuro-dermatological association between psoriasis and depression is significant. Different immune markers involved in the pathogenesis of depression and psoriasis also show the bidirectional association between them. However, this association between psoriasis and depression is positively correlated, but more work is required to answer why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression.

Keywords: depression; neuro-dermatology; psoriasis; skin-brain axis.

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Conflict of interest statement

Competing interest: The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.. Prisma flow chart showing the selection of studies.
See this image and copyright information in PMC

References

    1. Strain JJ. Globalization of psychosomatic medicine. Gen Hosp Psychiatry. 2017;48:62–64. - PubMed
    1. Brown GE, Malakouti M, Sorenson E, et al. Psychodermatology. Adv Psychosom Med. 2015;34:123–134. - PubMed
    1. Leon A, Levin EC, Koo JY. Psychodermatology: an overview. Semi Cutan Med Surg. 2013;32:64–67. - PubMed
    1. Karam RA, Zidan HE, Khater MH. Polymorphisms in the TNF-α and IL-10 gene promoters and risk of psoriasis and correlation with disease severity. Cytokine. 2014;66:101–105. - PubMed
    1. Parisi R, Symmons DP, Griffiths CE, et al. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013;133:377–385. - PubMed