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Multicenter Study
. 2021 Nov;37(11):3549-3554.
doi: 10.1007/s00381-021-05258-w. Epub 2021 Jun 29.

TROPHY registry - status report

U W Thomale  1 , C Auer  2 , P Spennato  3 , A Schaumann  4 , P Behrens  4 , S Gorelyshev  5 , E Bogoslovskaia  6 , A Shulaev  7 , A Kabanian  8 , A Seliverstov  9 , A Alexeev  10 , O Ozgural  11 , G Kahilogullari  11 , M Schuhmann  12 , R Jimenez-Guerra  13 , N Wittayanakorn  14 , A Sukharev  15 , J Marquez-Rivas  16 , S Linsler  17 , A El Damaty  18 , P Vacek  19 , M Lovha  20 , R Guzman  21 , S Stricker  21 , T Beez  22 , C Wiegand  23 , M Azab  24 , D Buis  25 , M Sáez  26 , S Fleck  27 , C Dziugan  28 , A Ferreira  29 , T Radovnicky  30 , C Bührer  4 , S Lam  28 , S Sgouros  31 , J Roth  32 , S Constantini  32 , S Cavalheiro  33 , G Cinalli  3 , A V Kulkarni  34 , H C Bock  35
Affiliations
Multicenter Study

TROPHY registry - status report

U W Thomale et al. Childs Nerv Syst. 2021 Nov.

Abstract

Introduction: The TROPHY registry has been established to conduct an international multicenter prospective data collection on the surgical management of neonatal intraventricular hemorrhage (IVH)-related hydrocephalus to possibly contribute to future guidelines. The registry allows comparing the techniques established to treat hydrocephalus, such as external ventricular drainage (EVD), ventricular access device (VAD), ventricular subgaleal shunt (VSGS), and neuroendoscopic lavage (NEL). This first status report of the registry presents the results of the standard of care survey of participating centers assessed upon online registration.

Methods: On the standard of treatment forms, each center indicated the institutional protocol of interventions performed for neonatal post-hemorrhagic hydrocephalus (nPHH) for a time period of 2 years (Y1 and Y2) before starting the active participation in the registry. In addition, the amount of patients enrolled so far and allocated to a treatment approach are reported.

Results: According to the standard of treatment forms completed by 56 registered centers, fewer EVDs (Y1 55% Y2 46%) were used while more centers have implemented NEL (Y1 39%; Y2 52%) to treat nPHH. VAD (Y1 66%; Y2 66%) and VSGS (Y1 42%; Y2 41%) were used at a consistent rate during the 2 years. The majority of the centers used at least two different techniques to treat nPHH (43%), while 27% used only one technique, 21% used three, and 7% used even four different techniques. Patient data of 110 infants treated surgically between 9/2018 and 2/2021 (13% EVD, 15% VAD, 30% VSGS, and 43% NEL) were contributed by 29 centers.

Conclusions: Our results emphasize the varying strategies used for the treatment of nPHH. The international TROPHY registry has entered into a phase of growing patient recruitment. Further evaluation will be performed and published according to the registry protocol.

Keywords: External ventricular drainage; Infant hydrocephalus; Neuroendoscopic shunt; Posthemorrhagic hydrocephalus; Subgaleal shunt; TROPHY; Ventricular access device.

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Conflict of interest statement

The authors have no conflict of interest to declare with the content of this manuscript.

Figures

Fig. 1
Fig. 1
International participation in the TROPHY registry. A Distribution of centers per country registered. B Amount of cases enrolled per country
Fig. 2
Fig. 2
Number of different interventions used per center according to the standard treatment forms
Fig. 3
Fig. 3
A Total number of patients enrolled in the TROPHY registry over time. B Techniques used as initial treatment for nPHHC in the enrolled patient cohort
See this image and copyright information in PMC

References

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