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. 2021 Sep;47(9):1037-1040.
doi: 10.1007/s00134-021-06445-8. Epub 2021 Jun 29.

Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients

Philippe Meersseman #  1   2 , Joris Blondeel #  3   4 , Greet De Vlieger  5   6 , Schalk van der Merwe  7   8 , Diethard Monbaliu  9   10 ; Collaborators Leuven Liver Transplant program
Collaborators, Affiliations

Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients

Philippe Meersseman et al. Intensive Care Med. 2021 Sep.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Temporal evolution of liver tests, treatments & MRCP images. For each individual patient (rows), the temporal evolution of liver enzymes, along with time points when critical diagnostic or treatment events occurred (left). Levels of gamma-glutamyltransferase (Gamma GT), alkaline phosphatase (ALP), aspartate transaminase (AST) and alanine transaminase (ALT) are projected on the left vertical axis and expressed as U/L, total bilirubin is projected on the right vertical axis and is expressed as mg/dl. VV-ECMO veno-venous extracorporeal membrane oxygenation, ERCP endoscopic retrograde cholangiopancreatography, MARS molecular absorbent recirculating system, LT liver transplantation. Cholestasis was defined as alkaline phosphatase > 1.5 times the upper limit. Also shown are a representative MRCP image for each patient (right) illustrating: in patient 1, diffuse beading of the intrahepatic biliary system (*); in patient 2 and 3, diffuse beading of the intrahepatic biliary ducts (*) and focal strictures on the left and right hepatic ducts (arrows); in patient 4, focal strictures on the right hepatic duct (arrows) and diminished arborisation of the intrahepatic biliary tree (#). All these findings are consistent with the diagnosis of ‘Secondary Sclerosing Cholangitis in Critically Ill Patients’ (SSC-CIP)
See this image and copyright information in PMC

Comment in

  • Matters of time.
    Lupia T, De Rosa FG. Lupia T, et al. Intensive Care Med. 2021 Oct;47(10):1175-1176. doi: 10.1007/s00134-021-06452-9. Epub 2021 Jun 16. Intensive Care Med. 2021. PMID: 34132843 No abstract available.
  • Ketamine-induced cholangiopathy in ARDS patients.
    de Tymowski C, Dépret F, Dudoignon E, Legrand M, Mallet V; Keta-Cov Research Group. de Tymowski C, et al. Intensive Care Med. 2021 Oct;47(10):1173-1174. doi: 10.1007/s00134-021-06482-3. Epub 2021 Jul 27. Intensive Care Med. 2021. PMID: 34313797 Free PMC article. No abstract available.

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