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Review
. 2021 Jul;60(7):862-871.
doi: 10.1007/s00120-021-01569-7. Epub 2021 Jun 29.

[Management of chemotherapy side effects and their long-term sequelae]

[Article in German]
Isabella M Zraik  1 , Yasmine Heß-Busch  2
Affiliations
Review

[Management of chemotherapy side effects and their long-term sequelae]

[Article in German]
Isabella M Zraik et al. Urologe A. 2021 Jul.

Abstract
in English, German

Various chemotherapies are used to treat testicular cancer. The most common therapy regimens are BEP (cisplatin, etoposide, bleomycin), carboplatin mono (AUC 7), PEI (cisplatin, etoposide, ifosfamide), TIP (cisplatin, ifosfamide, paclitaxel) and GOP (gemcitabine, oxaliplatin, paclitaxel). This is accompanied by acute and late toxicities. These include general side effects such as anemia, neutropenia, nausea, vomiting, diarrhea, mucositis or paravasation as well as special toxicities like ototoxicity, nephrotoxicity, pulmonary toxicity, neurotoxicity or Raynaud's syndrome. Since young men are usually affected, the possible long-term consequences such as hypogonadism, infertility or the metabolic syndrome are very relevant. Accordingly, adequate management of the possible side effects and long-term consequences in the context of the use of chemotherapy is essential.

Zur Behandlung von Hodentumoren werden verschiedene Chemotherapien verwendet. Die häufigsten Therapieregime sind PEB (Cisplatin, Etoposid, Bleomycin), Carboplatin Monotherapie (AUC 7), PEI (Cisplatin, Etoposid, Ifosfamid), TIP (Cisplatin, Ifosfamid, Paclitaxel) und GOP (Gemcitabin, Oxaliplatin, Paclitaxel). Hiermit gehen verschiedene Akut- und Spättoxizitäten einher. Hierzu zählen allgemeine Nebenwirkungen wie Anämie, Neutropenie, Übelkeit, Erbrechen, Durchfälle, Mukositis oder auch Paravasate sowie spezielle Toxizitäten wie Ototoxizität, Nephrotoxizität, pulmonale Toxizität, Neurotoxizität oder das Raynaud-Syndrom. Da in der Regel junge Männer betroffen sind, sind gerade auch die möglichen Langzeitfolgen wie Hypogonadismus, Infertilität oder das metabolische Syndrom sehr relevant. Dementsprechend ist ein adäquates Management der möglichen Nebenwirkungen und Langzeitfolgen im Rahmen des Einsatzes von Chemotherapien essentiell.

Keywords: Anemia; Nausea and vomiting; Quality of life; Testicular cancer; Toxicities.

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References

Literatur

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