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Review
. 2020:1296:137-150.
doi: 10.1007/978-3-030-59038-3_8.

Pineal Gland Tumor Microenvironment

Joham Choque-Velasquez  1 , Szymon Baluszek  2   3 , Roberto Colasanti  4   5 , Sajjad Muhammad  6 , Juha Hernesniemi  7
Affiliations
Review

Pineal Gland Tumor Microenvironment

Joham Choque-Velasquez et al. Adv Exp Med Biol. 2020.

Abstract

A wide and heterogeneous variety of tumors develop from the pineal gland. Pineal parenchymal tumors, germ cell tumors, and glial tumors represent most of them. The molecular profiles and tumor microenvironment play a key role in the development and progression of pineal gland tumors. Consequently, they represent important factors that may determine the efficacy of the different treatment modalities and the clinical outcome. Current literature is scarce regarding the microenvironment research of pineal gland tumors. Here, we review the cellular and molecular profile of the pineal gland tumor microenvironment.

Keywords: ATRX; BRAF; DICER1; DROSHA; Germ cell tumors; Germinomas; Gliomas; Hypomethylation; Isocitrate dehydrogenase; KBTBD4; Microenvironment; Pineal gland; Pineal parenchymal tumors; Pineoblastomas; Pineocytomas..

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References

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