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. 2021 Jun:61 Suppl 1:S125-S132.
doi: 10.1002/jcph.1892.

Understanding the Role of Pharmacometrics-Based Clinical Decision Support Systems in Pediatric Patient Management: A Case Study Using Lyv Software

Praneeth Jarugula  1 , Sarah Scott  2 , Vijay Ivaturi  1   3 , Andreas Noack  3 , Brady S Moffett  4 , Adnan Bhutta  2 , Jogarao V S Gobburu  1   3
Affiliations

Understanding the Role of Pharmacometrics-Based Clinical Decision Support Systems in Pediatric Patient Management: A Case Study Using Lyv Software

Praneeth Jarugula et al. J Clin Pharmacol. 2021 Jun.

Abstract

Pharmacometrics could play a key role in shifting pediatric pharmacotherapy from dosing for an average patient to individualizing dosing. Clinicians can have these quantitative tools at their disposal without requiring significant training through the development of clinical decision support systems with easy-to-use interfaces that have a back-end analysis engine or pharmacometric model that uses extensive electronic health record data to predict an individualized dose for each patient. There has been increased development of these clinical decision support systems recently, and for these tools to make the proper breakthrough into clinical practice, it is of utmost importance to perform rigorous testing to ensure adequate predictive performance. In this article, we walk through the components of a decision support tool and the testing required to determine its robustness using an example of a decision support tool we developed for vancomycin dosing in pediatrics.

Keywords: clinical decision support systems; pharmacometrics; precision dosing.

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References

    1. Barker CIS, Standing JF, Kelly LE, et al. Pharmacokinetic studies in children: recommendations for practice and research. Arch Dis Child. 2018;103:695-702.
    1. Carpenter D, Gonzalez D, Retsch-Bogart G, et al. Methodological and ethical issues in pediatric medication safety research. Pediatrics. 2017; 140(3):1-9.
    1. Allen CH, Garbe MC, Lees J, et al. Off-label medication use in children, more common than we think: a systematic review of the literature. J Okla State Med Assoc. 2018;111(8): 776-783.
    1. Green DJ, Zineh I, Burckart G, et al. Pediatric drug development: outlook for science-based innovation. Clin Pharmacol Ther. 2018;103(3):376-78.
    1. Mehrotra N, Bhattaram A, Earp JC, et al. Role of quantitative clinical pharmacology in pediatric approval and labeling. Drug Metab Dispos. 2016; 44(7):924-33.

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