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. 2021 Jun 30;59(11):e405-e408.
doi: 10.1515/cclm-2021-0623. Print 2021 Oct 26.

The high frequency of anti-PF4/heparin antibodies in patients with COVID-19 is neither related to heparin treatment or to an increased incidence of thrombosis

Tiffany Pascreau  1   2 , Marie-Christine Ballester  3 , Patrick Van Dreden  4 , Sara Zia-Chahabi  1 , Benjamin Zuber  5 , Jad Choucair  6 , Roselyne Bironien  1 , Eric Farfour  1 , Marc Vasse  1   2
Affiliations
Free article

The high frequency of anti-PF4/heparin antibodies in patients with COVID-19 is neither related to heparin treatment or to an increased incidence of thrombosis

Tiffany Pascreau et al. Clin Chem Lab Med. .
Free article
No abstract available

Keywords: COVID-19; anti-PF4/heparin antibodies; heparin induced thrombocytopenia.

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References

    1. Riker, RR, May, TL, Fraser, GL, Gagnon, DJ, Bandara, M, Zemrak, WR, et al.. Heparin‐induced thrombocytopenia with thrombosis in COVID‐19 adult respiratory distress syndrome. Res Pract Thromb Haemostasis 2020;4:936–41. https://doi.org/10.1002/rth2.12390.
    1. Patell, R, Khan, A, Bogue, T, Merrill, M, Koshy, A, Bindal, P, et al.. Heparin induced thrombocytopenia antibodies in COVID‐19. Am J Hematol 2020;95:E295–6. https://doi.org/10.1002/ajh.25935.
    1. Daviet, F, Guervilly, C, Baldesi, O, Bernard-Guervilly, F, Pilarczyk, E, Genin, A, et al.. Heparin-induced thrombocytopenia in severe COVID-19. Circulation 2020;142:1875–7. https://doi.org/10.1161/circulationaha.120.049015.
    1. Delrue, M, Siguret, V, Neuwirth, M, Brumpt, C, Voicu, S, Burlacu, R, et al.. Contrast between prevalence of HIT antibodies and confirmed HIT in hospitalized COVID-19 patients: a prospective study with clinical implications. Thromb Haemostasis 2020. https://doi.org/10.1055/a-1333-4688.
    1. He, X, Yao, F, Chen, J, Wang, Y, Fang, X, Lin, X, et al.. The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients. Sci Rep 2021;11:1830. https://doi.org/10.1038/s41598-021-81300-w.

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