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Case Reports
. 2021 Jun 29;14(6):e240944.
doi: 10.1136/bcr-2020-240944.

Diagnosis of an adenocarcinoma of Müllerian origin made as a result of its metastasis in the mouth floor

Mariana Silva Gandolfo  1 , Valeria Denninghoff  1   2 , Alejandra Avagnina  3 , Lidia Isabel Adler  4
Affiliations
Case Reports

Diagnosis of an adenocarcinoma of Müllerian origin made as a result of its metastasis in the mouth floor

Mariana Silva Gandolfo et al. BMJ Case Rep. .

Abstract

Metastases derived from primary tumours distant to the oral and maxillofacial region account for only 1% of all malignancies at that location, usually with a poor prognosis. In women, the primary tumours that most frequently metastasise to the oral cavity are breast adenocarcinomas affecting the jawbones and soft tissues (41% and 24%, respectively), followed by adrenal glands and female genital organs to the jawbones (8%), and female genital organs to the soft tissues (15%). Metastatic tumours of the mouth are a challenging diagnosis because of their exceptional occurrence. We report on the case of an 83-year-old woman who consulted for a bleeding ulcerated tumour on the floor of the mouth. A biopsy-confirmed metastasis of an adenocarcinoma of Müllerian origin. The oral lesion was the first sign of undetected cancer. The patient agreed to surgical resection and was further referred to palliative care for her symptoms.

Keywords: gynecological cancer; head and neck cancer; mouth; oral and maxillofacial surgery; pathology.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Ulcerated tumour located on the floor of the mouth. Size: 2.5 cm in anteroposterior direction ×1.5 cm transversely ×0.6 cm in height.
Figure 2
Figure 2
Ulcerated tumour in relation to the complete unadapted prosthesis.
Figure 3
Figure 3
Histological image of the lesion (H&E). Adenocarcinoma with a papillary pattern. Neoplastic cells showed hyperchromatic nuclei and moderate anisonucleosis (×200).
Figure 4
Figure 4
Immunohistochemical stainings of the mouth biopsy. (A) Cytokeratin 7 diffuse positivity. (B) PAX 8 nuclear staining. (C) TTF1 negative staining. (D) GATA 3 negative staining (×400).
See this image and copyright information in PMC

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