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. 2021 Jul;42(7):793-797.
doi: 10.15537/smj.2021.42.7.20210110.

Association between sex hormones and migraine in young Saudi females

Lubna I Al Asoom  1 , Modhi S Alajmi  1 , Reem R Alsudairi  1 , Abeer A AlShamlan  1 , Amal A Almomaten  1 , Asma A Alqarni  1 , Manal H Alshammari  1 , Nazish Rafique  1 , Rabia Latif  1 , Ahmed A Alsunni  1 , Dana A Almohazey  1 , Hind S Alsuwat  1 , Sayed Abdul Azeez  1 , Francis J Borgio  1
Affiliations

Association between sex hormones and migraine in young Saudi females

Lubna I Al Asoom et al. Saudi Med J. 2021 Jul.

Abstract

Objectives: To assess the sex hormone levels in young Saudi female migraineurs during a migraine attack and during pain-free periods and compare them with control subjects.

Methods: A case-control study involving 14 Saudi female migraineurs and 21 control subjects was conducted between December 2019 and March 2020. Demographic and disease history data were collected through participant interviews. Blood samples were drawn during the migraine attack and pain-free periods.

Results: Follicular (30.00±19.60; p<0.001) and luteal (39.79±11.45; p=0.037) estrogen levels were significantly higher in patients with non-menstrual related migraine (NMM), while luteal testosterone levels (1.10±0.31; p=0.023) were significantly higher in patients with menstrually related migraine (MM). Body mass index (BMI) was higher in patients with NMM (25.77±6.53; p=0.013), and it was found to be associated with follicular estrogen (p=0.016), progesterone (p=0.018), and pain intensity (p=0.042). Luteal estrogen level was significantly lower (13.96±7.88; p=0.036) in patients with luteal onset of attack.

Conclusion: High estrogen levels were found to mediate NMM, their effect being more pronounced with increase in BMI; whereas low luteal estrogen levels mediated MM. Young females with MM might have high luteal testosterone levels, and a compensatory protective role could be surmised accordingly.

Keywords: estrogen; migraine; migraineur; progesterone; testosterone.

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Figures

Figure 1
Figure 1
- Linear regression lines demonstrating the correlation of BMI with (a) estrogen during the follicular phase, (b) progesterone during the follicular phase, and (c) Migraine pain intensity by the visual analog scale.
See this image and copyright information in PMC

References

    1. Rafique N, Al-Asoom LI, Latif R, Alsunni AA, Salem AM, Alkhalifa ZH, et al. . Prevalence of migraine and its relationship with psychological stress and sleep quality in female university students in Saudi Arabia. J Pain Res 2020; 13: 2423–2430. - PMC - PubMed
    1. Vosoughi K, Stovner LJ, Steiner TJ, Moradi-Lakeh M, Fereshtehnejad SM, Farzadfar F, et al. . The burden of headache disorders in the Eastern Mediterranean Region, 1990-2016: findings from the global burden of disease study 2016. J Headache Pain 2019; 20: 40. - PMC - PubMed
    1. Muayqil T, Al-Jafen BN, Al-Saaran Z, Al-Shammari M, Alkthiry A, Muhammad WS, et al. . Migraine and headache prevalence and associated comorbidities in a large Saudi sample. Eur Neurol 2018; 79: 126–134. - PubMed
    1. Vgontzas A, Burch R.. Episodic migraine with and without aura: key differences and implications for pathophysiology, management, and assessing risks. Curr Pain Headache Rep 2018; 22: 78. - PubMed
    1. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd ed. Cephalalgia 2018; 38: 1–211. - PubMed