Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep:150:111169.
doi: 10.1016/j.chaos.2021.111169. Epub 2021 Jun 25.

Design and simulation of mechanical ventilators

Affiliations

Design and simulation of mechanical ventilators

Abdellah El-Hadj et al. Chaos Solitons Fractals. 2021 Sep.

Abstract

During this period of COVID-19 pandemic, the lack of medical equipment (like ventilators) leads to complications arising in the medical field. A low-cost ventilator seems to be an alternative substitute to fill the lacking. This paper presents a numerical analysis for predicting the delivered parameters of a low-cost mechanical ventilator. Based on several manufactured mechanical ventilators, two proposed designs are investigated in this study. Fluid-structure interaction (FSI) analysis is used for solving any problems with the first design, and computational fluid dynamic (CFD) analysis with moving boundary is used for solving any issues with the second design. For this purpose, ANSYS Workbench platform is used to solve the set of equations. The results showed that the Ambu-bag-based mechanical ventilator exhibited difficulties in controlling ventilation variables, which certainly will cause serious health problems such as barotrauma. The mechanical ventilator based on piston-cylinder is more satisfactory with regards to delivered parameters to the patient. The ways to obtain pressure control mode (PCM) and volume control mode (VCM) are identified. Finally, the ventilator output is highly affected by inlet flow, length of the cylinder, and piston diameter.

Keywords: CFD, COVID-19; Fluid-structure interaction; Mechanical ventilator.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig 1:
Fig. 1
The physiology of the breathing system .
Fig 2:
Fig. 2
The operating principle scheme of mechanical ventilation .
Fig 3:
Fig. 3
Typical curves of flow, pressure, and volume in the case of VCM .
Fig 4:
Fig. 4
Design of the Ambu-bag based on a low-cost mechanical ventilator . .
Fig 5:
Fig. 5
Stress-strain curves for the silicon rubber material.
Fig 6:
Fig. 6
Flowchart of the FSI solution procedure .
Fig 7:
Fig. 7
Boundary conditions and generated mesh for the structural domain.
Fig 8:
Fig. 8
Boundary conditions and generated mesh for fluid domain.
Fig 9:
Fig. 9
The second mechanical ventilator design. .
Fig 10:
Fig. 10
The mesh and boundary conditions of the fluid domain of the piston-cylinder-based design.
Fig 11:
Fig. 11
Total displacement of the ventilator with silicon-rubber Ambu-bag, at 1 s. (PVC material, 100% O2, inlet flow = 12 l/min, UAZ = 0.09 m).
Fig 12:
Fig. 12
Mesh history of fluid domain during one cycle of breathing. (PVC material, 100% O2, inlet flow = 12 l/min, UAZ = 0.09 m).
Fig 13:
Fig. 13
Surface streamlines history on the vertical plane for the first design. (PVC material, 100% O2, inlet flow = 12 l/min, UAZ = 0.09 m).
Fig 14:
Fig. 14
Displacement uz of point1 and point 2 (PVC material, 100% O2, inlet flow = 12 l/min, UAZ = 0.09 cm).
Fig 15:
Fig. 15
Outlet flow rate history (100% O2, inlet flow = 12 l/min, UAZ = 0.09 cm).
Fig 16:
Fig. 16
Outlet flow rate history for different compression displacements (UAZ) (Silicon rubber material, 100% O2, inlet flow = 12 l/min).
Fig 17:
Fig. 17
Mesh displacement at different moments of the piston-cylinder system. (100% O2, inlet flow = 12 l/min, uniformly rectilinear, Lc = 150 × 10−3 m, Dp = 37 × 10−3 m).
Fig 18:
Fig. 18
Flow rate at the outlet and the inlet of Piston-cylinder ventilator for cases A and B. (100% O2, inlet flow = 12 l/min, Lc = 150 × 10−3 m, Dp = 37 × 10−3 m).
Fig 19:
Fig. 19
Volume history of Piston-cylinder ventilator for cases A and B. (100% O2, inlet flow = 12 l/min, Lc = 150 × 10−3 m, Dp = 37 × 10−3 m).
Fig 20:
Fig. 20
PCM and VCM modes of mechanical ventilation .
Fig 21:
Fig. 21
Surface streamlines on the vertical plane of the piston-cylinder ventilator. (100% O2, inlet flow = 12 l/min, uniformly rectilinear, Lc = 150 × 10−3 m, Dp = 37 × 10−3 m).
Fig 22:
Fig. 22
Surface streamlines on the horizontal plane of the piston-cylinder ventilator. (100% O2, inlet flow = 12 l/min, uniformly rectilinear, Lc = 150 × 10−3 m, Dp = 37 × 10−3 m).
Fig 23:
Fig. 23
Effects of different parameters on the outlet flow. (100% O2, uniformly rectilinear Upx).

References

    1. Jaimes A., André N.M., Chappie J.S., Millet J.K., Whittaker G.R. Phylogenetic analysis and structural modeling of SARSCoV-2 spike protein reveals an evolutionary distinct and proteolytically sensitive activation loop. J Mol Biol. 2020 doi: 10.1016/j.jmb.2020.04.009. - DOI - PMC - PubMed
    1. Tian S., Hu W., Niu L., Liu H., Xu H., Xiao S.Y. Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer. J Thorac Oncol. 2020 doi: 10.1016/J.JTHO.2020.02.010. - DOI - PMC - PubMed
    1. Ayittey F.K., Ayittey M.K., Chiwero N.B., Kamasah J.S., Dzuvor C. Economic impacts of Wuhan 2019-nCoV on China and the world. J Med Virol. 2020 doi: 10.1002/jmv.25706. - DOI - PMC - PubMed
    1. Pfefferbaum B., North C.S. Mental health and the Covid-19 pandemic. New Engl J Med. 2020;383:510–512. doi: 10.1056/NEJMp2008017. - DOI - PubMed
    1. Velavan T.P., Meyer C.G. The COVID-19 epidemic. Trop Med Int Health. 2020;25:278. doi: 10.1111/tmi.13383. - DOI - PMC - PubMed

LinkOut - more resources