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Review
. 2021 Jun 23:16:4225-4237.
doi: 10.2147/IJN.S310952. eCollection 2021.

Current Strategies and Potential Prospects of Nanomedicine-Mediated Therapy in Inflammatory Bowel Disease

Fengqian Chen  1 , Qi Liu  2 , Yang Xiong  3 , Li Xu  4
Affiliations
Review

Current Strategies and Potential Prospects of Nanomedicine-Mediated Therapy in Inflammatory Bowel Disease

Fengqian Chen et al. Int J Nanomedicine. .

Abstract

Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are highly debilitating. IBDs are associated with the imbalance of inflammatory mediators within the inflamed bowel. Conventional drugs for IBD treatment include anti-inflammatory medications and immune suppressants. However, they suffer from a lack of bioavailability and high dose-induced systemic side effects. Nanoparticle (NP)-derived therapy improves therapeutic efficacy and increases targeting specificity. Recent studies have shown that nanomedicines, based on bowel disease's pathophysiology, are a fast-growing field. NPs can prolong the circulation period and reduce side effects by improving drug encapsulation and targeted delivery. Here, this review summarizes various IBD therapies with a focus on NP-derived applications, whereas their challenges and future perspectives have also been discussed.

Keywords: inflammatory bowel disease; nanomedicine applications; nanoparticles; targeted delivery.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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