Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Mar 30;8(6):ofab158.
doi: 10.1093/ofid/ofab158. eCollection 2021 Jun.

A Narrative Review on the Role of Staphylococcus aureus Bacteriuria in S. aureus Bacteremia

Franziska Schuler  1 , Peter J Barth  2 , Silke Niemann  1 , Frieder Schaumburg  1
Affiliations
Review

A Narrative Review on the Role of Staphylococcus aureus Bacteriuria in S. aureus Bacteremia

Franziska Schuler et al. Open Forum Infect Dis. .

Abstract

Staphylococcus aureus bacteriuria (SABU) can occur in patients with S. aureus bacteremia (SAB). However, little is known on the (molecular) pathomechanisms of the renal passage of S. aureus. This review discusses the epidemiology and pathogenesis of SABU in patients with SAB and identifies knowledge gaps. The literature search was restricted to the English language. The prevalence of SABU in patients with SAB is 7.8%-39% depending on the study design. The main risk factor for SABU is urinary tract catheterization. SABU in SAB patients is associated with increased mortality. Given present evidence, hematogenous seeding-as seen in animal models-and the development of micro-abscesses best describe the translocation of S. aureus from blood to urine. Virulence factors that might be involved are adhesion factors, sortase A, and coagulase, among others. Other potential routes of bacterial translocation (eg, transcytosis, paracytosis, translocation via "Trojan horses") were identified as knowledge gaps.

Keywords: Staphylococcus aureus; bacteremia; bacteriuria; pathogenesis; renal abscess.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Translocation of Staphylococcus aureus from blood to urine.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Tong SY, Davis JS, Eichenberger E, et al. . Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev 2015; 28:603–61. - PMC - PubMed
    1. Al Mohajer M, Darouiche RO. Staphylococcus aureus bacteriuria: source, clinical relevance, and management. Curr Infect Dis Rep 2012; 14:601–6. - PubMed
    1. Kramer TS, Schlosser B, Gruhl D, et al. . Staphylococcus aureus bacteriuria as a predictor of in-hospital mortality in patients with Staphylococcus aureus bacteremia. Results of a retrospective cohort study. J Clin Med 2020; 9:508. - PMC - PubMed
    1. Lee BK, Crossley K, Gerding DN. The association between Staphylococcus aureus bacteremia and bacteriuria. Am J Med 1978; 65:303–6. - PubMed
    1. Karakonstantis S, Kalemaki D. Evaluation and management of Staphylococcus aureus bacteriuria: an updated review. Infection 2018; 46:293–301. - PubMed