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Clinical Features and Outcomes of Streptococcus anginosus Group Infective Endocarditis: A Multicenter Matched Cohort Study

Francesc Escrihuela-Vidal et al. Open Forum Infect Dis. .

Abstract

Background: Although Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption.

Methods: We performed a retrospective analysis of prospectively collected data from consecutive patients with definite SAG endocarditis in 28 centers in Spain and Italy. A comparison between cases due to SAG endocarditis and viridans group streptococci (VGS) or Streptococcus gallolyticus group (SGG) was performed in a 1:2 matched analysis.

Results: Of 5336 consecutive cases of definite endocarditis, 72 (1.4%) were due to SAG and matched with 144 cases due to VGS/SGG. SAG endocarditis was community acquired in 64 (88.9%) cases and affected aortic native valve in 29 (40.3%). When comparing SAG and VGS/SGG endocarditis, no significant differences were found in septic shock (8.3% vs 3.5%, P = .116); valve disorder, including perforation (22.2% vs 18.1%, P = .584), pseudoaneurysm (16.7% vs 8.3%, P = .108), or prosthesis dehiscence (1.4% vs 6.3%, P = .170); paravalvular complications, including abscess (25% vs 18.8%, P = .264) and intracardiac fistula (5.6% vs 3.5%, P = .485); heart failure (34.7% vs 38.9%, P = .655); or embolic events (41.7% vs 32.6%, P = .248). Indications for surgery (70.8% vs 70.8%; P = 1) and mortality (13.9% vs 16.7%; P = .741) were similar between groups.

Conclusions: SAG endocarditis is an infrequent but serious condition that presents a prognosis similar to that of VGS/SGG.

Keywords: Streptococcus anginosus; Streptococcus gallolyticus; infective endocarditis; viridans group streptococci.

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References

    1. Lefort A, Lortholary O, Casassus P, et al. Beta-Hemolytic Streptococci Infective Endocarditis Study Group. Comparison between adult endocarditis due to beta-hemolytic streptococci (serogroups A, B, C, and G) and Streptococcus milleri: a multicenter study in France. Arch Intern Med 2002; 162:2450–6. - PubMed
    1. Escolà-Vergé L, Fernández-Hidalgo N, Larrosa MN, Fernandez-Galera R, Almirante B. Secular trends in the epidemiology and clinical characteristics of Enterococcus faecalis infective endocarditis at a referral center (2007–2018) [manuscript published online ahead of print 6 January 2021]. Eur J Clin Microbiol Infect Dis 2021. doi:10.1007/s10096-020-04117-x. - PubMed
    1. Habib G, Erba PA, Iung B, et al. EURO-ENDO Investigators. Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study. Eur Heart J 2019; 40:3222–32. - PubMed
    1. Yew HS, Murdoch DR. Global trends in infective endocarditis epidemiology. Curr Infect Dis Rep 2012; 14:367–72. - PubMed
    1. Fernández Hidalgo N, Gharamti AA, Aznar ML, et al. . Beta-hemolytic streptococcal infective endocarditis: characteristics and outcomes from a large, multinational cohort. Open Forum Infect Dis 2020; 7:1–9. - PMC - PubMed

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