Preliminary clinical evaluation of a new topical corticosteroid, halopredone acetate, as compared to fluocinonide
- PMID: 341903
Preliminary clinical evaluation of a new topical corticosteroid, halopredone acetate, as compared to fluocinonide
Abstract
17,21-Bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon), a new corticosteroid for topical use, was compared with fluocinonide in a double blind sequential study. The tests were made on a total of 16 patients affected with psoriasis and exudative dermatitis. In each patient, the symmetrically distributed skin lesions were separately treated with either halopredone acetate or the reference compound. The two active substances were in the same concentration (0.05%) in the same carrier (cream), and both reduced the subjective and objective symptoms of these skin conditions. No statistically significant differences were observed between the two medicated areas. Haloperidone acetate, the excipients of the cream and the reference compound were all excellently tolerated.
Similar articles
-
Clinical investigation of halopredone acetate, a new topical steroid, in dermatology. Controlled study.Arzneimittelforschung. 1977;27(12):2404-6. Arzneimittelforschung. 1977. PMID: 341905 Clinical Trial.
-
Clinical study of the relationship between dose and response to halopredone acetate in dermatoses.Arzneimittelforschung. 1977;27(12):2399-403. Arzneimittelforschung. 1977. PMID: 341904 Clinical Trial.
-
Treatment of non-inflammatory dermatoses. A double-blind comparison of 1% hydrocortisone plus 10% urea and 0.05% fluocinonide.Practitioner. 1978 Aug;221(1322):265-7. Practitioner. 1978. PMID: 364458 Clinical Trial. No abstract available.
-
Double-blind comparison of topical halcinonide and fluocinonide in the treatment of psoriasis.Int J Dermatol. 1976 Sep;15(7):534-7. doi: 10.1111/j.1365-4362.1976.tb00726.x. Int J Dermatol. 1976. PMID: 786910 Clinical Trial. No abstract available.
-
Double-blind comparisons of topically applied steroids. A critical review of methods.Br J Dermatol. 1967 Aug-Sep;79(8):460-74. doi: 10.1111/j.1365-2133.1967.tb11534.x. Br J Dermatol. 1967. PMID: 5341922 Review. No abstract available.
Cited by
-
Comparative study of the vasoconstrictor activity of halopredone acetate in a modified McKenzie test.Eur J Clin Pharmacol. 1978 Dec 18;14(5):325-9. doi: 10.1007/BF00611901. Eur J Clin Pharmacol. 1978. PMID: 729625
-
Strategies for using topical corticosteroids in children and adults with eczema.Cochrane Database Syst Rev. 2022 Mar 11;3(3):CD013356. doi: 10.1002/14651858.CD013356.pub2. Cochrane Database Syst Rev. 2022. PMID: 35275399 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Miscellaneous