Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 May 31;18(3):1926759.
doi: 10.1080/21645515.2021.1926759. Epub 2021 Jun 30.

Role of gut microbiome on immunotherapy efficacy in melanoma

Stefano Bibbò  1 , Gianluca Ianiro  1 , Federica Giambò  1 , Carlo Romano Settanni  1 , Giovanni Cammarota  1 , Antonio Gasbarrini  1
Affiliations
Review

Role of gut microbiome on immunotherapy efficacy in melanoma

Stefano Bibbò et al. Hum Vaccin Immunother. .

Abstract

The gut microbiota is considered a key component in many aspects of cancer pathophysiology and response to therapy. In particular, in recent years intriguing evidences has been emerging regarding the role of the intestinal microbiota in the response to immunotherapy and in promoting the development of adverse events, such as colitis. For this reason, studies are being carried out both on pre-clinical models and on humans to study how to predict the response to immunotherapy through the study of the microbiota or how to improve its clinical response through modulation. Promising data have recently been reported through modulation by probiotics or prebiotics, and in particular by fecal microbiota transplantation. The aim of this review is to analyze the evidence regarding the role of the microbiota in immunotherapy with a particular focus on melanoma.

Keywords: checkpoint inhibitors; colitis; fecal microbiota transplantation; immunotherapy; microbiota; oncology; prebiotic; probiotic.

PubMed Disclaimer

References

    1. Kamada N, Nunez G.. Role of the gut microbiota in the development and function of lymphoid cells. J Immunol. 2013;190:1389–6. doi: 10.4049/jimmunol.1203100. - DOI - PMC - PubMed
    1. Viggiano D, Ianiro G, Vanella G, Bibbò S, Bruno G, Simeone G, Mele G. Gut barrier in health and disease: focus on childhood. Eur Rev Med Pharmacol Sci. 2015;19:1077–85. PMID: 25855935. - PubMed
    1. Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014;157:121–41. doi: 10.1016/j.cell.2014.03.011. - DOI - PMC - PubMed
    1. Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A. 2010;107:12204–09. doi: 10.1073/pnas.0909122107. - DOI - PMC - PubMed
    1. Galluzzi L, Chan TA, Kroemer G, Wolchok JD, López-Soto A. The hallmarks of successful anticancer immunotherapy. Sci Transl Med. 2018;10:10. doi: 10.1126/scitranslmed.aat7807. - DOI - PubMed