Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Sep 15;204(6):621-622.
doi: 10.1164/rccm.202105-1273ED.

Can Metformin Downshift the Gears of Aging to Slow Emphysema Progression?

Affiliations
Editorial

Can Metformin Downshift the Gears of Aging to Slow Emphysema Progression?

Irina Petrache et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic of effects of metformin in the mouse model of cigarette smoke–induced emphysema. mTERT = mouse telomerase. Created with Biorender.com.

Comment on

  • Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment.
    Polverino F, Wu TD, Rojas-Quintero J, Wang X, Mayo J, Tomchaney M, Tram J, Packard S, Zhang D, Cleveland KH, Cordoba-Lanus E, Owen CA, Fawzy A, Kinney GL, Hersh CP, Hansel NN, Doubleday K, Sauler M, Tesfaigzi Y, Ledford JG, Casanova C, Zmijewski J, Konhilas J, Langlais PR, Schnellmann R, Rahman I, McCormack M, Celli B. Polverino F, et al. Am J Respir Crit Care Med. 2021 Sep 15;204(6):651-666. doi: 10.1164/rccm.202012-4510OC. Am J Respir Crit Care Med. 2021. PMID: 34033525 Free PMC article.

References

    1. Polverino F, Wu TD, Rojas-Quintero J, Wang X, Mayo J, Tomchaney M, et al. Metformin: experimental and clinical evidence for a potential role in emphysema treatment. Am J Respir Crit Care Med. 2021;204 - PMC - PubMed
    1. Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, et al. Clinical pharmacokinetics of metformin. Clin Pharmacokinet. 2011;50:81–98. - PubMed
    1. Rena G, Hardie DG, Pearson ER. The mechanisms of action of metformin. Diabetologia. 2017;60:1577–1585. - PMC - PubMed
    1. Pernicova I, Korbonits M. Metformin--mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol. 2014;10:143–156. - PubMed
    1. Novelle MG, Ali A, Diéguez C, Bernier M, de Cabo R. Metformin: a hopeful promise in aging research. Cold Spring Harb Perspect Med. 2016;6:a025932. - PMC - PubMed