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Review
. 2022;20(2):412-431.
doi: 10.2174/1570159X19666210629151303.

SARS-Cov-2 Damage on the Nervous System and Mental Health

Mohamed Said Boulkrane  1 , Victoria Ilina  1 , Roman Melchakov  1 , Mikhail Arisov  2 , Julia Fedotova  3   4   5 , Lucia Gozzo  6 , Filippo Drago  6 , Weihong Lu  7 , Alexey Sarapultsev  5 , Vadim Tseilikman  5 , Denis Baranenko  1
Affiliations
Review

SARS-Cov-2 Damage on the Nervous System and Mental Health

Mohamed Said Boulkrane et al. Curr Neuropharmacol. 2022.

Abstract

The World Health Organization declared the pandemic situation caused by SARSCoV- 2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mildmoderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness, the possible damages on the brain should be considered, too.

Keywords: COVID-19; SARS-CoV-2; brain disorders; mental health; neuroinvasive potential; neurological diseases.

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