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. 2020 Nov 25;4(1):e000859.
doi: 10.1136/bmjpo-2020-000859. eCollection 2020.

COVID-19 in pregnancy: the foetal perspective-a systematic review

Rajani Dube  1 , Subhranshu Sekhar Kar  2
Affiliations

COVID-19 in pregnancy: the foetal perspective-a systematic review

Rajani Dube et al. BMJ Paediatr Open. .

Abstract

Objective: We aimed to conduct a systematic review of the available literature to determine the effects of confirmed cases of COVID-19 in pregnant women from the foetal perspective by estimation of mother to child transmission, perinatal outcome and possible teratogenicity.

Methods: Data sources: eligible studies between 1 November 2019 and 10 August 2020 were retrieved from PubMed, Embase, LitCovid, Google Scholar, EBSCO MEDLINE, CENTRAL, CINAHL, MedRXiv, BioRXiv and Scopus collection databases. English language case reports, case series and cohort studies of SARS-CoV-2 confirmed pregnant women with data on perinatal outcome, congenital anomalies and mother to child transmission were analysed.

Results: 38 case reports, 34 cohort and case series describing 1408 neonates were included for evidence acquisition of mother to child transmission. 29 case reports and 31 case series and cohort studies describing 1318 foetuses were included for the evaluation of perinatal outcome and congenital anomalies. A pooled proportion of 3.67% neonates had positive SARS-CoV-2 viral RNA nasopharyngeal swab results and 7.1% had positive cord blood samples. 11.7% of the placenta, 6.8% of amniotic fluid, 9.6% of faecal and rectal swabs and none of the urine samples were positive. The rate of preterm labour was 26.4% (OR=1.45, 95% CI 1.03 to 2.03 with p=0.03) and caesarean delivery (CS) was 59.9% (OR=1.54, 95% CI 1.17 to 2.03 with p=0.002). The most common neonatal symptom was breathing difficulty (1.79%). Stillbirth rate was 9.9 per 1000 total births in babies born to COVID-19 mothers.

Conclusion: Chances of mother to child transmission of the SARS-CoV-2 virus is low. The perinatal outcome for the foetus is favourable. There is increased chances of CS but not preterm delivery. The stillbirth and neonatal death rates are low. There are no reported congenital anomalies in babies born to SARS CoV-2 positive mothers.

Keywords: data collection; microbiology; mortality; neonatology; virology.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Image-PRISMA-1-Mother to child transmission.
Figure 2
Figure 2
Image-PRISMA-2-Perinatal outcome.
See this image and copyright information in PMC

References

    1. Rasmussen SA, Smulian JC, Lednicky JA, et al. . Coronavirus disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol 2020;222:415–26. 10.1016/j.ajog.2020.02.017 - DOI - PMC - PubMed
    1. Muhidin S, Behboodi Moghadam Z, Vizheh M. Analysis of maternal coronavirus infections and neonates born to mothers with 2019-nCoV; a systematic review. Arch Acad Emerg Med 2020;8:e49. - PMC - PubMed
    1. Ellington S, Strid P, Tong VT, et al. . Characteristics of women of reproductive age with Laboratory-Confirmed SARS-CoV-2 infection by pregnancy status — United States, January 22–June 7, 2020. MMWR Morb Mortal Wkly Rep 2020;69:769–75. 10.15585/mmwr.mm6925a1 - DOI - PMC - PubMed
    1. Rajewska A, Mikołajek-Bedner W, Lebdowicz-Knul J, et al. . COVID-19 and pregnancy – where are we now? A review. J Perinat Med 2020;48:428–34. 10.1515/jpm-2020-0132 - DOI - PubMed
    1. Woodward A. A pregnant mother infected with the coronavirus gave birth, and her baby tested positive 30 hours later. Available: https://www.businessinsider.com/wuhan-coronavirus-in-infant-born-from-in... [Accessed June 15, 2020].

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