Transglutaminase 2 Inhibition for Prevention of Mucosal Damage in Celiac Disease
- PMID: 34192435
- PMCID: PMC8514117
- DOI: 10.1056/NEJMe2107502
Transglutaminase 2 Inhibition for Prevention of Mucosal Damage in Celiac Disease
Comment on
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A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease.N Engl J Med. 2021 Jul 1;385(1):35-45. doi: 10.1056/NEJMoa2032441. N Engl J Med. 2021. PMID: 34192430 Clinical Trial.
References
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- Molberg O, Mcadam SN, Körner R, et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 1998; 4: 713–7. - PubMed
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- van de Wal Y, Kooy Y, van Veelen P, et al. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 1998; 161: 1585–8. - PubMed
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