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. 2021 Jul:196:129-134.
doi: 10.1016/j.puhe.2021.05.027. Epub 2021 Jun 27.

Dramatic decline in new HIV diagnoses in persons born in France in a large nationwide HIV cohort

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Dramatic decline in new HIV diagnoses in persons born in France in a large nationwide HIV cohort

A Le Guillou et al. Public Health. 2021 Jul.

Abstract

Objectives: As trends in new HIV diagnoses represent a measure of the HIV epidemic, we conducted a 6-year longitudinal study to evaluate the change in rates of new HIV diagnosis, stratified by birthplace, HIV risk groups and CD4 cell count at diagnosis in a large French multicentre cohort.

Study design: We performed a retrospective cohort study using data from the mainland French Dat'AIDS cohort.

Methods: Data were obtained for subjects with a new HIV diagnosis date between 2013 and 2018. HIV diagnosis date was defined as the date of the first known positive HIV serology.

Results: Between 2013 and 2018, a total of 68,376 people living with HIV (PLHIV) were followed in the Dat'AIDS cohort; 9543 persons were newly diagnosed with HIV. The annual number of new HIV diagnoses decreased from 1856 in 2013, to 1149 in 2018 (-38.1%), P = 0.01; it was more pronounced among subjects born in France, from 858 to 484 (-43.6%), P < 0.01, than in those born abroad (-23.8%, from 821 to 626, P = 0.13). Among subjects born in France, the decrease over the period was -46.7% among men who have sex with men (MSM), -43.5% for heterosexual women and -33.3% for heterosexual men.

Conclusion: Our findings show changes in HIV epidemiology in PLHIV born in France, with a decline around 40% in new HIV diagnoses, and a more pronounced decrease among MSM and heterosexual women. Our results support the long-term effectiveness of the antiretroviral therapy as a prevention strategy among the various tools for HIV prevention.

Keywords: 90–90–90 target; Antiretroviral therapy; Cascade of care; Dat’AIDS cohort; HIV; HIV epidemiology; New HIV diagnoses; PrEP; TasP; Treatment as prevention; UNAIDS.

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