Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017-2018 season

doi:10.1038/s41598-021-92895-5

Observational Study

. 2021 Jun 30;11(1):13587.

doi: 10.1038/s41598-021-92895-5.

Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017-2018 season

Núria Soldevila^{1

2}, Lesly Acosta³, Ana Martínez^{4

5}, Pere Godoy^{4

5}, Núria Torner⁴, Cristina Rius^{4

6}, Mireia Jané^{4

7

5}, Angela Domínguez^{4

7}; Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group

Collaborators, Affiliations

Collaborators

Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group:
M Alsedà, J Álvarez, C Arias, P J Balañà, I Barrabeig, N Camps, M Carol, J Ferràs, G Ferrús, N Follia, P Bach, S Minguell, I Parrón, E Plasència, M R Sala-Farré, R Torra, J Torres, M A Marcos, M M Mosquera, A Vilella, A Antón, T Pumarola, M Campins, D García, A Oller Perez-Hita, E Espejo, N Freixas, M Riera Garcia, E Maraver, D Mas, R Pérez, J Rebull, J Pou, G García-Pardo, M Olona, F Barcenilla, D Castellana, G Navarro-Rubio, L Force, J M Mòdol-Deltell, G Mena, L Matas, A Alvarez, J M Torrel

Affiliations

¹ CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. nsoldevila@ub.edu.
² Departament de Medicina, Universitat de Barcelona, C/Casanova, 143, 08036, Barcelona, Spain. nsoldevila@ub.edu.
³ Universitat Politècnica de Catalunya-BCNTECH, Barcelona, Spain.
⁴ CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
⁵ Agència de Salut Pública de Catalunya, Generalitat de Catalunya, Barcelona, Spain.
⁶ Agència de Salut Pública de Barcelona, Barcelona, Spain.
⁷ Departament de Medicina, Universitat de Barcelona, C/Casanova, 143, 08036, Barcelona, Spain.

PMID: 34193898
PMCID: PMC8245597
DOI: 10.1038/s41598-021-92895-5

Observational Study

Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017-2018 season

Núria Soldevila et al. Sci Rep. 2021.

. 2021 Jun 30;11(1):13587.

doi: 10.1038/s41598-021-92895-5.

Authors

Collaborators

Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group:
M Alsedà, J Álvarez, C Arias, P J Balañà, I Barrabeig, N Camps, M Carol, J Ferràs, G Ferrús, N Follia, P Bach, S Minguell, I Parrón, E Plasència, M R Sala-Farré, R Torra, J Torres, M A Marcos, M M Mosquera, A Vilella, A Antón, T Pumarola, M Campins, D García, A Oller Perez-Hita, E Espejo, N Freixas, M Riera Garcia, E Maraver, D Mas, R Pérez, J Rebull, J Pou, G García-Pardo, M Olona, F Barcenilla, D Castellana, G Navarro-Rubio, L Force, J M Mòdol-Deltell, G Mena, L Matas, A Alvarez, J M Torrel

Affiliations

¹ CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. nsoldevila@ub.edu.
² Departament de Medicina, Universitat de Barcelona, C/Casanova, 143, 08036, Barcelona, Spain. nsoldevila@ub.edu.
³ Universitat Politècnica de Catalunya-BCNTECH, Barcelona, Spain.
⁴ CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
⁵ Agència de Salut Pública de Catalunya, Generalitat de Catalunya, Barcelona, Spain.
⁶ Agència de Salut Pública de Barcelona, Barcelona, Spain.
⁷ Departament de Medicina, Universitat de Barcelona, C/Casanova, 143, 08036, Barcelona, Spain.

PMID: 34193898
PMCID: PMC8245597
DOI: 10.1038/s41598-021-92895-5

Erratum in

Author Correction: Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017-2018 season.
Soldevila N, Acosta L, Martínez A, Godoy P, Torner N, Rius C, Jané M, Domínguez A; Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group. Soldevila N, et al. Sci Rep. 2021 Oct 12;11(1):20566. doi: 10.1038/s41598-021-99937-y. Sci Rep. 2021. PMID: 34642443 Free PMC article. No abstract available.

Abstract

Influenza is an important cause of severe illness and death among patients with underlying medical conditions and in the elderly. The aim of this study was to investigate factors associated with ICU admission and death in patients hospitalized with severe laboratory-confirmed influenza during the 2017-2018 season in Catalonia. An observational epidemiological case-to-case study was carried out. Reported cases of severe laboratory-confirmed influenza requiring hospitalization in 2017-2018 influenza season were included. Mixed-effects regression analysis was used to estimate the factors associated with ICU admission and death. A total of 1306 cases of hospitalized severe influenza cases were included, of whom 175 (13.4%) died and 217 (16.6%) were ICU admitted. Age 65-74 years and ≥ 75 years and having ≥ 2 comorbidities were positively associated with death (aOR 3.19; 95%CI 1.19-8.50, aOR 6.95, 95%CI 2.76-1.80 and aOR 1.99; 95%CI 1.12-3.52, respectively). Neuraminidase inhibitor treatment and pneumonia were negatively associated with death. The 65-74 years and ≥ 75 years age groups were negatively associated with ICU admission (aOR 0.41; 95%CI 0.23-0.74 and aOR 0.30; 95%CI 0.17-0.53, respectively). A factor positively associated with ICU admission was neuraminidase inhibitor treatment. Our results support the need to investigate the worst outcomes of hospitalized severe cases, distinguishing between death and ICU admission.

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Conflict of interest statement

The authors declare no competing interests.

Figures

**Figure 1**
Flow chart of severe hospitalized influenza cases.

**Figure 2**
Factors associated with death in hospitalized severe influenza patients according to age group, influenza type, patients admitted to ICU and patients with pneumonia. *Hemoglobinopathy, severe neuromuscular disease or cognitive dysfunction. COPD: chronic obstructive pulmonary disease, NAI: neuraminidase inhibitors.

**Figure 3**
Factors associated with ICU admission in hospitalized severe influenza patients according to age group, influenza type and patients with pneumonia. NAI: neuraminidase inhibitors.

See this image and copyright information in PMC

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References

1. Treanor JJ. Influenza viruses, including avian influenza and swine influenza. In: Bennett JE, Dolin R, Blaser MJ, editors. Principles and Practice of Infectious Diseases. 9. Elsevier; 2020. pp. 2143–2176.
1. World Health Organization. Influenza (Seasonal). (Accessed 15 Oct 2020) https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal) (2018).
1. Chaudhari PP, Monuteaux MC, Pannaraj PS, Khemani RG, Bachur RG. Age-stratified risk of critical illness in young children presenting to the emergency department with suspected influenza. J. Pediatr. 2019;215:132–138. doi: 10.1016/j.jpeds.2019.08.041. - DOI - PubMed
1. Wong PL, et al. The effect of age on clinical characteristics, hospitalization and mortality of patients with influenza-related illness at a tertiary care centre in Malaysia. Influenza. Other. Respir. Viruses. 2020;14:286–293. doi: 10.1111/irv.12691. - DOI - PMC - PubMed
1. Martínez A, et al. Risk factors associated with severe outcomes in adult hospitalized patients according to influenza type and subtype. PLoS ONE. 2019;14:e0210353. doi: 10.1371/journal.pone.0210353. - DOI - PMC - PubMed

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[1] Treanor JJ. Influenza viruses, including avian influenza and swine influenza. In: Bennett JE, Dolin R, Blaser MJ, editors. Principles and Practice of Infectious Diseases. 9. Elsevier; 2020. pp. 2143–2176.

[2] Treanor JJ. Influenza viruses, including avian influenza and swine influenza. In: Bennett JE, Dolin R, Blaser MJ, editors. Principles and Practice of Infectious Diseases. 9. Elsevier; 2020. pp. 2143–2176.

[3] World Health Organization. Influenza (Seasonal). (Accessed 15 Oct 2020) https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal) (2018).

[4] World Health Organization. Influenza (Seasonal). (Accessed 15 Oct 2020) https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal) (2018).

[5] Chaudhari PP, Monuteaux MC, Pannaraj PS, Khemani RG, Bachur RG. Age-stratified risk of critical illness in young children presenting to the emergency department with suspected influenza. J. Pediatr. 2019;215:132–138. doi: 10.1016/j.jpeds.2019.08.041. - DOI - PubMed

[6] Chaudhari PP, Monuteaux MC, Pannaraj PS, Khemani RG, Bachur RG. Age-stratified risk of critical illness in young children presenting to the emergency department with suspected influenza. J. Pediatr. 2019;215:132–138. doi: 10.1016/j.jpeds.2019.08.041. - DOI - PubMed

[7] Wong PL, et al. The effect of age on clinical characteristics, hospitalization and mortality of patients with influenza-related illness at a tertiary care centre in Malaysia. Influenza. Other. Respir. Viruses. 2020;14:286–293. doi: 10.1111/irv.12691. - DOI - PMC - PubMed

[8] Wong PL, et al. The effect of age on clinical characteristics, hospitalization and mortality of patients with influenza-related illness at a tertiary care centre in Malaysia. Influenza. Other. Respir. Viruses. 2020;14:286–293. doi: 10.1111/irv.12691. - DOI - PMC - PubMed

[9] Martínez A, et al. Risk factors associated with severe outcomes in adult hospitalized patients according to influenza type and subtype. PLoS ONE. 2019;14:e0210353. doi: 10.1371/journal.pone.0210353. - DOI - PMC - PubMed

[10] Martínez A, et al. Risk factors associated with severe outcomes in adult hospitalized patients according to influenza type and subtype. PLoS ONE. 2019;14:e0210353. doi: 10.1371/journal.pone.0210353. - DOI - PMC - PubMed

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Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017-2018 season

Collaborators

Affiliations

Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017-2018 season

Authors

Collaborators

Affiliations

Erratum in

Abstract

Conflict of interest statement

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Erratum in

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