Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jun 14:15:680938.
doi: 10.3389/fnins.2021.680938. eCollection 2021.

Directions of Deep Brain Stimulation for Epilepsy and Parkinson's Disease

Ying-Chang Wu  1 , Ying-Siou Liao  1 , Wen-Hsiu Yeh  2 , Sheng-Fu Liang  1   3 , Fu-Zen Shaw  2   4
Affiliations
Review

Directions of Deep Brain Stimulation for Epilepsy and Parkinson's Disease

Ying-Chang Wu et al. Front Neurosci. .

Abstract

Background: Deep brain stimulation (DBS) is an effective treatment for movement disorders and neurological/psychiatric disorders. DBS has been approved for the control of Parkinson disease (PD) and epilepsy.

Objectives: A systematic review and possible future direction of DBS system studies is performed in the open loop and closed-loop configuration on PD and epilepsy.

Methods: We searched Google Scholar database for DBS system and development. DBS search results were categorized into clinical device and research system from the open-loop and closed-loop perspectives.

Results: We performed literature review for DBS on PD and epilepsy in terms of system development by the open loop and closed-loop configuration. This study described development and trends for DBS in terms of electrode, recording, stimulation, and signal processing. The closed-loop DBS system raised a more attention in recent researches.

Conclusion: We overviewed development and progress of DBS. Our results suggest that the closed-loop DBS is important for PD and epilepsy.

Keywords: PD; closed-loop; deep brain stimulation; epilepsy; open loop.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic plot of a technical system for deep brain stimulation (top) and its flowchart of signal processing (bottom).
FIGURE 2
FIGURE 2
Publications utilizes the open loop and closed-loop architecture in the control of PD (A) and epilepsy (B).
See this image and copyright information in PMC

References

    1. Anderson D. N., Osting B., Vorwerk J., Dorval A. D., Butson C. R. (2018). Optimized programming algorithm for cylindrical and directional deep brain stimulation electrodes. J. Neural Eng. 15:026005. 10.1088/1741-2552/aaa14b - DOI - PubMed
    1. Arfin S. K., Sarpeshkar R. (2011). An energy-efficient, adiabatic electrode stimulator with inductive energy recycling and feedback current regulation. IEEE Trans. Biomed. circ. Syst. 6 1–14. 10.1109/tbcas.2011.2166072 - DOI - PubMed
    1. Arlotti M., Marceglia S., Foffani G., Volkmann J., Lozano A. M., Moro E., et al. (2018). Eight-hours adaptive deep brain stimulation in patients with Parkinson disease. Neurology 90 e971–e976. - PMC - PubMed
    1. Arlotti M., Rossi L., Rosa M., Marceglia S., Priori A. (2016). An external portable device for adaptive deep brain stimulation (aDBS) clinical research in advanced Parkinson’s disease. Med. Eng. Phys. 38 498–505. 10.1016/j.medengphy.2016.02.007 - DOI - PubMed
    1. Avestruz A.-T., Santa W., Carlson D., Jensen R., Stanslaski S., Helfenstine A., et al. (2008). A 5$\mu $ W/channel spectral analysis IC for chronic bidirectional brain–machine interfaces. IEEE J. Solid State Circ. 43 3006–3024. 10.1109/jssc.2008.2006460 - DOI

LinkOut - more resources