Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Jun 23;9(6):e04291.
doi: 10.1002/ccr3.4291. eCollection 2021 Jun.

Doege-Potter syndrome in a facial solitary fibrous tumor: Diagnose and clinical management discussion

Roser Fort-Culillas  1 , Rebeca Barahona San Millán  2 , Isabel Garcia-Fructuoso  1 , Angels Quera González  3 , Armand Grau Martín  4   5 , Montserrat Puigdemont Guinart  6 , Jordi Rubió-Casadevall  1   5   7 , Mònica Recasens Sala  2   5 , Rut Porta Balanyà  1   5   8
Affiliations
Case Reports

Doege-Potter syndrome in a facial solitary fibrous tumor: Diagnose and clinical management discussion

Roser Fort-Culillas et al. Clin Case Rep. .

Abstract

Doege-Potter syndrome is a rare hypoglycemic paraneoplastic disorder. This case describes that severe and symptomatic hypoglycemia can occasionally be due to a rare malignant neoplasm, and the differential diagnosis of malignancy should not be overlooked in this setting.

Keywords: Doege‐Potter syndrome; STAT6; big‐IGF2; hypoglycemia; paraneoplastic syndrome; solitary fibrous tumor.

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

FIGURE 1
FIGURE 1
Histology and immunohistochemistry of SFT. A, Facial biopsy: spindle tumor cells with fibroblastic appearance and uniform extension with a patternless architecture and branched vessels with thin walls. B, Liver biopsy: tumor of similar characteristics, but more cellular, with greater nuclear atypia and with evidence of mitotic figures (arrows). C, Internal control: The CD34 marker is negative in tumor cells and positive in vascular walls. D, STAT6 staining shows intense, diffuse, and a uniform nuclear expression in the spindle tumor cells. E‐F: CT images. E, Large expansive lesion in the right chewing area. F, Liver with multiple metastatic lesions. The two largest lesions, in segment III and segment VIII of 110 and 150 mm, respectively
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Zafar H, Takimoto CH, Weiss G. Doege‐Potter syndrome: hypoglycemia associated with malignant solitary fibrous tumor. Med Oncol. 2003;20(4):403‐408. 10.1385/MO:20:4:403 - DOI - PubMed
    1. Khowaja A, Johnson‐Rabbett B, Bantle J, Moheet A. Hypoglycemia mediated by paraneoplastic production of insulin like growth factor‐2 from a malignant renal solitary fibrous tumor ‐ clinical case and literature review. BMC Endocr Disord. 2014;14:49. 10.1186/1472-6823-14-49 - DOI - PMC - PubMed
    1. Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL. Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol. 2014;27(3):390‐395. 10.1038/modpathol.2013.164 - DOI - PubMed
    1. Schöffski P, Timmermans I, Hompes D, et al. Clinical presentation, natural history, and therapeutic approach in patients with solitary fibrous tumor: a retrospective analysis. Sarcoma. 2020;2020:1385978. 10.1155/2020/1385978 - DOI - PMC - PubMed
    1. Leyvraz S, Zweifel M, Jundt G, et al. Long‐term results of a multicenter SAKK trial on high‐dose ifosfamide and doxorubicin in advanced or metastatic gynecologic sarcomas. Ann Oncol. 2006;17(4):646‐651. 10.1093/annonc/mdl020 - DOI - PubMed

Publication types