BCOR immunohistochemistry, but not SATB2 immunohistochemistry, is a sensitive and specific diagnostic biomarker for central nervous system tumours with BCOR internal tandem duplication

Laïla Mardi¹, Arnault Tauziède-Espariat^{1

2

3}, Delphine Guillemot⁴, Gaelle Pierron^{4

5}, Priscille Gigant¹, Leïla Mehdi¹, Charlotte Berthaud¹, Noémie Pucelle¹, Joelle Lacombe¹, Lauren Hasty¹, Ellen Wahler¹, Fabrice Chrétien^{1

3}, Emmanuèle Lechapt^{1

3}, Pascale Varlet^{1

2

3}

Affiliations

¹ Department of Neuropathology, GHU Paris, Psychiatry and Neurosciences, Sainte-Anne Hospital.
² Institute of Psychiatry and Neurosciences de Paris (IPNP), UMR S1266, INSERM, IMA-BRAIN.
³ Université de Paris.
⁴ Laboratory of Somatic Genetics, Curie Institute Hospital.
⁵ Paris-Sciences-Lettres, Curie Institute Research Centre, INSERMU830, Paris, France.

Laïla Mardi et al. Histopathology. 2021 Nov.

. 2021 Nov;79(5):891-894.

doi: 10.1111/his.14439. Epub 2021 Sep 20.

¹ Department of Neuropathology, GHU Paris, Psychiatry and Neurosciences, Sainte-Anne Hospital.
² Institute of Psychiatry and Neurosciences de Paris (IPNP), UMR S1266, INSERM, IMA-BRAIN.
³ Université de Paris.
⁴ Laboratory of Somatic Genetics, Curie Institute Hospital.
⁵ Paris-Sciences-Lettres, Curie Institute Research Centre, INSERMU830, Paris, France.

No abstract available

References

1. Sturm D, Orr BA, Toprak UH et al. New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell 2016; 164; 1060-1072.
1. Yoshida Y, Nobusawa S, Nakata S et al. CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication: a comparison with its counterparts in the kidney and soft tissue. Brain Pathol. 2018; 28; 710-720.
1. Tauziède-Espariat A, Pierron G, Siegfried A et al. The EP300:BCOR fusion extends the genetic alteration spectrum defining the new tumoral entity of ‘CNS tumors with BCOR internal tandem duplication’. Acta Neuropathol. Commun. 2020; 8; 178.
1. Ludwig K, Alaggio R, Zin A et al. BCOR-CCNB3 undifferentiated sarcoma-does immunohistochemistry help in the identification? Pediatr. Dev. Pathol. 2017; 20; 321-329.
1. Rao S, Mitra S, Sugur H et al. Central nervous system high grade neuroepithelial tumor with BCOR immunopositivity: is there a molecular heterogeneity? Brain Tumor Pathol. 2021; 38; 41-49.