Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Sep;31(5):e12999.
doi: 10.1111/bpa.12999. Epub 2021 Jul 1.

Astrocytes for brain repair: More than just a neuron's sidekick

Rebecca Z Weber  1   2 , Patrick Perron  1 , Ruslan Rust  1   2
Affiliations
Review

Astrocytes for brain repair: More than just a neuron's sidekick

Rebecca Z Weber et al. Brain Pathol. 2021 Sep.

Abstract

Transplantation of glial enriched progenitors provides therapeutic effects on axonal damage, cognitive and motor function following white matter stroke.

Keywords: brain injury; cell therapy; glial cells; ischemia; stroke.

PubMed Disclaimer

Conflict of interest statement

The author declares no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

FIGURE 1
FIGURE 1
Glial enriched progenitors promote functional recovery after white matter stroke. Induced pluripotent stem cells are generated from patient‐derived cells. These cells are differentiated toward a glial enriched progenitor (GEP) phenotype by activation of HIF with DFX. Transplantation of GEPs promotes myelin repair and improves cognitive and motor function
See this image and copyright information in PMC

References

    1. Schmidt R, Seiler S, Loitfelder M. Longitudinal change of small‐vessel disease‐related brain abnormalities. J Cereb Blood Flow Metab. 2016;36:26–39. - PMC - PubMed
    1. Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, et al. White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke. 2006;37:1391–8. - PubMed
    1. Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, et al. 3K3A‐APC stimulates post‐ischemic neuronal repair by human neural stem cells in mice. Nat Med. 2016;22:1050–5. - PMC - PubMed
    1. Andres RH, Horie N, Slikker W, Keren‐Gill H, Zhan K, Sun G, et al. Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain. Brain. 2011;134:1777–89. - PMC - PubMed
    1. Halliday MR, Rege SV, Ma Q, Zhao Z, Miller CA, Winkler EA, et al. Accelerated pericyte degeneration and blood‐brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease. J Cereb Blood Flow Metab. 2016;36:216–27. - PMC - PubMed