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Review
. 2021 Jun 14;13(6):2038.
doi: 10.3390/nu13062038.

Chrysin: Perspectives on Contemporary Status and Future Possibilities as Pro-Health Agent

Monika Stompor-Gorący  1 , Agata Bajek-Bil  2 , Maciej Machaczka  1   3
Affiliations
Review

Chrysin: Perspectives on Contemporary Status and Future Possibilities as Pro-Health Agent

Monika Stompor-Gorący et al. Nutrients. .

Abstract

Chrysin belongs to the group of natural polyphenols. It can be found, among others, in honey, propolis and fruits and has a wide range of biological activities, including the prevention of oxidative stress, inflammation, neurodegeneration and carcinogenesis. Being a part of the human diet, chrysin is considered to be a promising compound to be used in the prevention of many diseases, including cancers, diabetes and neurodegenerative diseases such as Alzheimer's or Parkinson's. Nevertheless, due to the low solubility of chrysin in water and under physiological conditions, its bioavailability is low. For this reason, attempts at its functionalization have been undertaken, aiming to increase its absorption and thus augment its in vivo therapeutic efficacy. The aim of this review is to summarize the most recent research on chrysin, including its sources, metabolism, pro-health effects and the effects of its functionalization on biological activity and pharmacological efficacy, evaluated both in vitro and in vivo.

Keywords: anticancer activity; antioxidants; chrysin; immunomodulators; neuroprotection.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of selected polyphenols.
Figure 2
Figure 2
Metabolism of chrysin in Rhodotorula glutinis, Absidia coerulea AM93, Absidia glauca AM 177 and Beauveria bassiana AM 278 cultures.
Figure 3
Figure 3
Two dominant products of chrysin metabolism in humans.
Figure 4
Figure 4
Examples of chrysin derivatives with proven anticancer activity.
See this image and copyright information in PMC

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