Cadmium-Associated Molecular Signatures in Cancer Cell Models

Abstract

The exposure of cancer cells to cadmium and its compounds is often associated with the development of more malignant phenotypes, thereby contributing to the acceleration of tumor progression. It is known that cadmium is a transcriptional regulator that induces molecular reprogramming, and therefore the study of differentially expressed genes has enabled the identification and classification of molecular signatures inherent in human neoplastic cells upon cadmium exposure as useful biomarkers that are potentially transferable to clinical research. This review recapitulates selected studies that report the detection of cadmium-associated signatures in breast, gastric, colon, liver, lung, and nasopharyngeal tumor cell models, as specifically demonstrated by individual gene or whole genome expression profiling. Where available, the molecular, biochemical, and/or physiological aspects associated with the targeted gene activation or silencing in the discussed cell models are also outlined.

Keywords: breast cancer; cadmium; colon cancer; differential expression; gastric cancer; gene signature; in vitro cell models; liver cancer; lung cancer; nasopharyngeal cancer.

Figure 1

Venn diagram illustrating the gene signature arrays in each cancer cell model examined and the overlapping areas among the model systems.