Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun 2;18(11):5982.
doi: 10.3390/ijerph18115982.

Decrease in All-Cause 30-Day Mortality after Bacteraemia over a 15-Year Period: A Population-Based Cohort Study in Denmark in 2000-2014

Mona Katrine Alberthe Holm  1 , Filip Jansåker  2   3 , Kim Oren Gradel  4   5 , Rikke Thoft Nielsen  1   6 , Christian Østergaard Andersen  1 , Jens Otto Jarløv  7 , Henrik Carl Schønheyder  8   9 , Jenny Dahl Knudsen  2
Affiliations

Decrease in All-Cause 30-Day Mortality after Bacteraemia over a 15-Year Period: A Population-Based Cohort Study in Denmark in 2000-2014

Mona Katrine Alberthe Holm et al. Int J Environ Res Public Health. .

Abstract

Introduction: Bacteraemia is a frequent infectious condition that strongly affects morbidity and mortality. The incidence is increasing worldwide. This study explores all-cause 30-day mortality after bacteraemia in two out of Denmark's five healthcare regions with approximately 2.4 million inhabitants.

Methods: Clinically significant bacteraemia episodes (n = 55,257) were identified from a geographically well-defined background population between 2000 and 2014, drawing on population-based data regarding bacterial species and vital status. All-cause 30-day mortality was assessed in relation to bacteraemia episodes, number of patients with analysed blood cultures and the background population.

Results: We observed a decreasing trend of all-cause 30-day mortality between 2000 and 2014, both in relation to the number of bacteraemia episodes and the background population. Mortality decreased from 22.7% of the bacteraemia episodes in 2000 to 17.4% in 2014 (annual IRR [95% CI]: 0.983 [0.979-0.987]). In relation to the background population, there were 41 deaths per 100,000 inhabitants in 2000, decreasing to 39 in 2014 (annual IRR [95% CI]: 0.988 [0.982-0.993]). Numbers of inhabitants, bacteraemia episodes, and analysed persons having BCs increased during the period.

Conclusions: All-cause 30-day mortality in patients with bacteraemia decreased significantly over a 15-year period.

Keywords: bacteraemia; bloodstream infection; epidemiology; mortality; population-based study.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(A) Background population. (B) Analysed BCs per 100,000 inhabitants. (C) First-time bacteraemia episodes per 100,000 inhabitants. (D) Deaths at 30 days per 100,000 inhabitants.
Figure 1
Figure 1
(A) Background population. (B) Analysed BCs per 100,000 inhabitants. (C) First-time bacteraemia episodes per 100,000 inhabitants. (D) Deaths at 30 days per 100,000 inhabitants.
Figure 1
Figure 1
(A) Background population. (B) Analysed BCs per 100,000 inhabitants. (C) First-time bacteraemia episodes per 100,000 inhabitants. (D) Deaths at 30 days per 100,000 inhabitants.
Figure 2
Figure 2
(A) Number of BCs analysed. (B) First-time bacteraemia episodes. (C) Death episodes at 30 days. (D) All-cause 30-day mortality in percentage.
Figure 2
Figure 2
(A) Number of BCs analysed. (B) First-time bacteraemia episodes. (C) Death episodes at 30 days. (D) All-cause 30-day mortality in percentage.
Figure 2
Figure 2
(A) Number of BCs analysed. (B) First-time bacteraemia episodes. (C) Death episodes at 30 days. (D) All-cause 30-day mortality in percentage.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Sogaard M., Norgaard M., Dethlefsen C., Schonheyder H.C. Temporal Changes in the Incidence and 30-Day Mortality associated with Bacteremia in Hospitalized Patients from 1992 through 2006: A Population-based Cohort Study. Clin. Infect. Dis. 2011;52:61–69. doi: 10.1093/cid/ciq069. - DOI - PubMed
    1. Wilson J., Elgohari S., Livermore D.M., Cookson B., Johnson A., Lamagni T., Chronias A., Sheridan E. Trends among pathogens reported as causing bacteraemia in England, 2004–2008. Clin. Microbiol. Infect. 2011;17:451–458. doi: 10.1111/j.1469-0691.2010.03262.x. - DOI - PubMed
    1. Skogberg K., Lyytikäinen O., Ollgren J., Nuorti J.P., Ruutu P. Population-based burden of bloodstream infections in Finland. Clin. Microbiol. Infect. 2012;18:E170–E176. doi: 10.1111/j.1469-0691.2012.03845.x. - DOI - PubMed
    1. Madsen K.M., Schønheyder H.C., Kristensen B., Sørensen H.T. Secular trends in incidence and mortality of bacteraemia in a Danish county 1981–1994. APMIS. 1999;107:346–352. doi: 10.1111/j.1699-0463.1999.tb01563.x. - DOI - PubMed
    1. Lam J.C., Gregson D.B., Robinson S., Somayaji R., Conly J.M., Parkins M.D. Epidemiology and Outcome Determinants of Staphylococcus aureus Bacteremia Revisited: A Population-Based Study. Infection. 2019;47:961–971. doi: 10.1007/s15010-019-01330-5. - DOI - PubMed

LinkOut - more resources