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. 2021 Jun 4;11(6):524.
doi: 10.3390/life11060524.

Ultrasound-Verified Peripheral Arthritis in Patients with HLA-B*35 Positive Spondyloarthritis

Daniela Šošo  1   2 , Jure Aljinović  1   2 , Sanja Lovrić Kojundžić  3 , Ivanka Marinović  1   2 , Esma Čečuk Jeličić  4 , Daniela Marasović Krstulović  5
Affiliations

Ultrasound-Verified Peripheral Arthritis in Patients with HLA-B*35 Positive Spondyloarthritis

Daniela Šošo et al. Life (Basel). .

Abstract

Background: We aimed to investigate possible association between the HLA-B*35 allele and peripheral arthritis, tenosynovitis and enthesitis.

Methods: Ultrasound of peripheral joints and tendons was performed in 72 HLA-B*35 positive patients with preliminary diagnosis of undifferentiated axial form of spondyloarthitis and joint and tendon pain. Patients with other known types of axial and peripheral spondyloarthritis were excluded as well as patients with other known types of arthritis.

Results: Pathological changes were found in the joints of 33 (46%) patients and on the tendons in 13 (18%) patients. The most common ultrasound findings were joint effusion and synovial proliferation with positive power Doppler signal grade 1. The most common ultrasound finding in patients with painful tendons was tenosynovitis. A higher disease activity and an increased incidence of elevated CRP (≥5 mg/L) were more often observed in the group with positive ultrasound findings.

Conclusion: In this study, we showed that the HLA-B*35 allele could be a potential risk factor for developing peripheral arthritis, but not for tenosynovits and enthesitis in patients with the undifferentiated axial form of spondyloarthritis. This result may influence the follow up of these patients, especially since it gives us an opportunity to consider the use of different types of DMARDs in the treatment of these patients.

Keywords: HLA-B*27; HLA-B*35; inflammatory bowel disease; peripheral arthritis; psoriasis; ultrasound; undifferentiated axial spondyloarthritis.

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Conflict of interest statement

The authors declare no conflict of interests.

Figures

Figure 1
Figure 1
Patients (n) with positive US finding in the group of 72 HLA-B * 35 SpA patients. Abbreviations: US: ultrasound; SpA: spondyloarthritis, PD: power Doppler.
See this image and copyright information in PMC

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References

    1. Dougados M., Hochberg M.C. Why is the concept of spondyloarthropathies important? Best Pract. Res. Clin. Rheumatol. 2002;16:495–505. doi: 10.1053/berh.2002.0253. - DOI - PubMed
    1. Raychaudhuri S.P., Deodhar A. The classification and diagnostic criteria of ankylosing spondylitis. J. Autoimmun. 2014;48:128–133. doi: 10.1016/j.jaut.2014.01.015. - DOI - PubMed
    1. Spondyloarthritis in over 16 s: Diagnosis and Management. National Institute for Health and Care; London, UK: 2017.
    1. Braun J., Sieper J. Building consensus on nomenclature and disease classification for ankylosing spondylitis: Results and discussion of a questionnaire prepared for the International Workshop on New Treatment Strategies in Ankylosing Spondylitis, Berlin, Germany, 18–19 January 2002. Ann. Rheum. Dis. 2002;61(Suppl. 3):iii61–iii67. - PMC - PubMed
    1. Rudwaleit M., van der Heijde D., Landewe R., Listing J., Akkoc N., Brandt J., Braun J., Chou C.T., Estévez E.C., Dougados M., et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): Validation and final selection. Ann. Rheum. Dis. 2009;68:777–783. doi: 10.1136/ard.2009.108233. - DOI - PubMed