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. 2021 Jun 4;14(11):3069.
doi: 10.3390/ma14113069.

Efficient Triazine Derivatives for Collagenous Materials Stabilization

Vanessa Gatto  1   2 , Silvia Conca  1 , Noemi Bardella  1 , Valentina Beghetto  1   2
Affiliations

Efficient Triazine Derivatives for Collagenous Materials Stabilization

Vanessa Gatto et al. Materials (Basel). .

Abstract

Nowadays, the need to reduce plastic waste and scantly biodegradable fossil-based products is of great importance. The use of leather as an alternative to synthetic materials is gaining renewed interest, but it is fundamental that any alternative to plastic-based materials should not generate an additional environmental burden. In the present work, a simple protocol for collagen stabilization mediated by 2-chloro-4,6-diethoxy-1,3,5-triazine (CDET) and a tert-amine has been described. Different tert-amines were tested in combination with CDET in a standard amidation reaction between 2-phenylethylamine and benzoic acid. Best performing condensation systems have been further tested for the cross-linking of both collagen powder and calf hides. The best results were achieved with CDET/NMM giving high-quality leather with improved environmental performances.

Keywords: collagen cross-linking; green chemistry; sustainable leather tanning; triazine amidation agents.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of CDET, DETMM(X), and different amine tested.
Scheme 1
Scheme 1
Dehydro-condensation reaction for the synthesis of amide N-phenethyl benzamide (III).
Scheme 2
Scheme 2
Cross-linking of collagen in the presence of CDET/tert-amine system.
See this image and copyright information in PMC

References

    1. Geyer R., Jambeck J.R., Law K.L. Production, use, and fate of all plastics ever made. Sci. Adv. 2017;3:e1700782. doi: 10.1126/sciadv.1700782. - DOI - PMC - PubMed
    1. Chen W.Q., Ciacci L., Sun N.N., Yoshioka T. Sustainable cycles and management of plastics: A brief review of RCR publications in 2019 and early 2020. Resour. Conserv. Recycl. 2020;159:104822–104828. doi: 10.1016/j.resconrec.2020.104822. - DOI
    1. Kabir E., Kaur R., Lee J., Kim K.H., Kwon E.E. Prospects of biopolymer technology as an alternative option for non-degradable plastics and sustainable management of plastic wastes. J. Clean. Prod. 2020;258:120536–120550. doi: 10.1016/j.jclepro.2020.120536. - DOI
    1. Mercado G., Dominguez M., Herrera I., Melgoza R.M. Are Polymers Toxic? Case Study: Environmental Impact of a Biopolymer. J. Environ. Sci. Eng. B. 2017;6:121–126. doi: 10.17265/2162-5263/2017.03.002. - DOI
    1. Nkanga U.J., Joseph J.J., Adams F.V., Uche O.U. Characterization of Bitumen/Plastic Blends for Flexible Pavement Application. Procedia Manuf. 2016;7:490–496. doi: 10.1016/j.promfg.2016.12.051. - DOI

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