Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jun 7;11(6):758.
doi: 10.3390/brainsci11060758.

Lyme Neuroborreliosis in Children

Affiliations
Review

Lyme Neuroborreliosis in Children

Sylwia Kozak et al. Brain Sci. .

Abstract

Lyme neuroborreliosis (LNB) is an infectious disease, developing after a tick bite and the dissemination of Borrelia burgdorferi sensu lato spirochetes reach the nervous system. The infection occurs in children and adults but with different clinical courses. Adults complain of radicular pain and paresis, while among the pediatric population, the most common manifestations of LNB are facial nerve palsy and/or subacute meningitis. Moreover, atypical symptoms, such as fatigue, loss of appetite, or mood changes, may also occur. The awareness of the various clinical features existence presented by children with LNB suspicion remains to be of the greatest importance to diagnose and manage the disease.

Keywords: children; diagnosis; facial nerve palsy; lyme borreliosis; meningitis; neuroborreliosis; neurological manifestations; treatment.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The most common symptoms in children with neuroborreliosis [3].
Figure 2
Figure 2
Presentation of the symptoms in children with Lyme neuroborreliosis caused by Borrelia garinii and Borrelia afzelii [36].

Similar articles

Cited by

References

    1. Steere A.C., Strle F., Wormser G.P., Hu L.T., Branda J.A., Hovius J.W.R., Li X., Mead P.S. Lyme Borreliosis. Nat. Rev. Dis. Primers. 2016;2:16090. doi: 10.1038/nrdp.2016.90. - DOI - PMC - PubMed
    1. Rauer S., Kastenbauer S., Hofmann H., Fingerle V., Huppertz H.-I., Hunfeld K.-P., Krause A., Ruf B., Dersch R. Guidelines for Diagnosis and Treatment in Neurology–Lyme Neuroborreliosis. GMS Ger. Med. Sci. 2020;18:18. doi: 10.3205/000279. - DOI - PMC - PubMed
    1. Södermark L., Sigurdsson V., Näs W., Wall P., Trollfors B. Neuroborreliosis in Swedish Children: A Population-Based Study on Incidence and Clinical Characteristics. Pediatric Infect. Dis. J. 2017;36:1052–1056. doi: 10.1097/INF.0000000000001653. - DOI - PubMed
    1. Hofmann H., Fingerle V., Hunfeld K.-P., Huppertz H.-I., Krause A., Rauer S., Ruf B. Consensus Group Cutaneous Lyme Borreliosis: Guideline of the German Dermatology Society. GMS Ger. Med. Sci. 2017 doi: 10.3205/000255. - DOI - PMC - PubMed
    1. Henningsson A.J., Lager M., Brännström R., Tjernberg I., Skogman B.H. The Chemokine CXCL13 in Cerebrospinal Fluid in Children with Lyme Neuroborreliosis. Eur. J. Clin. Microbiol. Infect. Dis. 2018;37:1983–1991. doi: 10.1007/s10096-018-3334-3. - DOI - PMC - PubMed

LinkOut - more resources