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Review
. 2021 Jun 8;9(6):614.
doi: 10.3390/vaccines9060614.

The Evolution of Cancer Immunotherapy

Meshaal Khan  1 , Ajay V Maker  1 , Shikha Jain  1
Affiliations
Review

The Evolution of Cancer Immunotherapy

Meshaal Khan et al. Vaccines (Basel). .

Abstract

Immunotherapy has changed the environment of cancer treatment by providing new and efficacious therapy options for many solid and hematologic malignancies. Although not a new field of oncology, immunotherapy has quickly developed into one of the most flourishing fields in medicine. In this review article, we explore key discoveries which helped to shape our current understanding of the immune system's role in neoplasms. Many landmark developments include the advancements in checkpoint inhibitors, monoclonal antibodies, CAR-T cells and anti-cancer vaccines. We also explore the drawbacks and efficacy of various categories of immunotherapy. Ongoing investigations within immunotherapy, such as the gut microbiome, combining checkpoint inhibitors and gene sequencing, continue to personalize treatments for cancer patients, providing exciting and endless possibilities for the future.

Keywords: CAR-T; cancer; checkpoint inhibitor; immunotherapy; monoclonal antibodies; vaccines.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
T cell function on tumor cells.
See this image and copyright information in PMC

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