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Review
. 2021 Jun 23;11(7):1140.
doi: 10.3390/diagnostics11071140.

IL-13Rα2 Is a Biomarker of Diagnosis and Therapeutic Response in Human Pancreatic Cancer

Toshio Fujisawa  1 , Bharat H Joshi  2 , Sho Takahashi  1 , Yusuke Takasaki  1 , Akinori Suzuki  1 , Koichi Ito  1 , Kazushige Ochiai  1 , Ko Tomishima  1 , Shigeto Ishii  1 , Raj K Puri  2 , Hiroyuki Isayama  1
Affiliations
Review

IL-13Rα2 Is a Biomarker of Diagnosis and Therapeutic Response in Human Pancreatic Cancer

Toshio Fujisawa et al. Diagnostics (Basel). .

Abstract

IL-13Rα2 is a high-affinity binding protein for its ligand IL-13 and a cancer-testis antigen as it is expressed in the testis. IL-13Rα2 is highly expressed in various cancers, including pancreatic cancer, and consists of three domains: extracellular, transmembrane, and cytoplasmic. The extracellular domain binds to the ligand to form a biologically active complex, which initiates signaling through AP-1 and other pathways. IL-13Rα2 is also expressed in diseased cells such as fibroblasts that are involved in various inflammatory diseases, including cancer. We have reported that IL-13Rα2 is a prognostic biomarker for malignant glioma, adrenocortical cancer, and pancreatic cancer. In pancreatic cancer, a small sample of tissue could be examined for the expression of IL-13Rα2 by using the endoscopic ultrasound-fine needle aspiration technique (EUS-FNA). In addition, a peptide-based targeted approach using Pep-1L peptide could be used to study the biodistribution and whole-body cancer imaging for the screening of pancreatic cancer in suspected subjects.

Keywords: AP-1 pathway; IL-13Rα2; cancer invasion; metastasis; pancreatic cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The schema of mechanisms by which IL-13Rα2 promotes cancer invasion of metastasis.
Figure 2
Figure 2
The schema of mechanisms increasing expression of IL-13Rα2 in cancer cells.
See this image and copyright information in PMC

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