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Review
. 2021 Jun 23;13(7):932.
doi: 10.3390/pharmaceutics13070932.

Film-Forming Systems for Dermal Drug Delivery

Larissa Carine Pünnel  1 , Dominique Jasmin Lunter  1
Affiliations
Review

Film-Forming Systems for Dermal Drug Delivery

Larissa Carine Pünnel et al. Pharmaceutics. .

Abstract

Film-forming formulations represent a novel form of sustained release dermatic products. They are applied to the skin as a liquid or semi-solid preparation. By evaporation of the volatile solvent on the skin, the polymer contained in the formulation forms a solid film. Various film-forming formulations were tested for their water and abrasion resistance and compared with conventional semi-solid formulations. Penetration and permeation studies of the formulations indicate a potential utility as transdermal therapeutic systems. They can be used as an alternative to patch systems to administer a variety of drugs in a topical way and may provide sustained release characteristics.

Keywords: film-forming system; polymeric formulation; topical drug delivery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structure of the skin with the different penetration depths of the dermal and transdermal systems.
Figure 2
Figure 2
Mechanism of film forming.
Figure 3
Figure 3
Film-forming emulsion, the oil droplets are embedded in a polymer matrix made of PVA and Eudragit NE (neutral PMMA (Polymethylmethacrylate) and Eudragit RS (quarternatry PMMA) for controlled drug release.
Figure 4
Figure 4
Illustration of different film-forming solution/gel.
See this image and copyright information in PMC

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