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Review
. 2021 Jun 3;13(11):2790.
doi: 10.3390/cancers13112790.

Indolent T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract (iTLPD-GI): A Review

Francesca Sanguedolce  1 , Magda Zanelli  2 , Maurizio Zizzo  3   4 , Stefano Luminari  5 , Giovanni Martino  6 , Alessandra Soriano  7 , Linda Ricci  8 , Cecilia Caprera  8 , Stefano Ascani  8
Affiliations
Review

Indolent T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract (iTLPD-GI): A Review

Francesca Sanguedolce et al. Cancers (Basel). .

Abstract

iTLPD-GI is a low-grade clonal T-cell lymphoproliferative disease arising in GI organs. It is an uncommon disease, and only recently has it been enlisted as a distinct provisional entity in the current WHO Classification. Data from the literature disclose high heterogeneity in terms of pathological and molecular features; on the other hand, establishing an accurate diagnosis of iTLPD-GI is of pivotal importance, since treatment options are different from that of other, more frequent lymphomas that arise in the gastrointestinal tract. In this review, we aimed to better define this novel entity, and to identify useful diagnostic biomarkers; moreover, we provide a biomarker-based approach to the diagnosis and describe the most common issues in differentiating iTLPD-GI from other neoplastic and non-neoplastic disorders.

Keywords: diagnosis; immunohistochemistry; indolent T-cell lymphoproliferative disorder of the gastro-intestinal tract (iTLPD-GI).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A gastric biopsy featuring diffuse infiltrate of the lamina propria and, focally, the submucosa (a); at higher magnification, lymphoid cells are small, monomorphic, with bland cytology (b). (Haematoxylin and eosin, original magnification 200× and 400×).
Figure 2
Figure 2
Immunoprofile of the 4 groups of iTLPD-GIs, stratified according to their coordinate CD4/CD8 expression.
Figure 3
Figure 3
Intense and diffuse expression of T-cell markers CD3 (a) and CD4 (b). (Haematoxylin and eosin, original magnification 400× and 200×).
Figure 4
Figure 4
Essential diagnostic algorithm to discriminate iTLPD-GI from its closest mimicries.
See this image and copyright information in PMC

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