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Review
. 2021 Jun 19;13(12):3061.
doi: 10.3390/cancers13123061.

Microbiota Alterations in Precancerous Colon Lesions: A Systematic Review

Francesca Aprile  1 , Giovanni Bruno  1 , Rossella Palma  2 , Maria Teresa Mascellino  3 , Cristina Panetta  2 , Giulia Scalese  1 , Alessandra Oliva  3 , Carola Severi  1 , Stefano Pontone  2
Affiliations
Review

Microbiota Alterations in Precancerous Colon Lesions: A Systematic Review

Francesca Aprile et al. Cancers (Basel). .

Abstract

Gut microbiota plays an important role in human health. It may promote carcinogenesis and is related to several diseases of the gastrointestinal tract. This study of microbial dysbiosis in the etiology of colorectal adenoma aimed to investigate the possible causative role of microbiota in the adenoma-carcinoma sequence and its possible preventive role. A systematic, PRISMA-guided review was performed. The PubMed database was searched using "adenoma microbiota" and selecting original articles between January 2010 and May 2020 independently screened. A higher prevalence of Proteobacteria, Fusobacteria, and Bacteroidetes phyla was observed in the fecal luminal and mucosa-associated microbiota of patients with adenoma. However, other studies provided evidence of depletion of Clostridium, Faecalibacterium, Bacteroides and Romboutsia. Results on the relationship between adenoma endoscopic resection and microbiota were inconsistent. In conclusion, none of the analyzed studies developed a predictive model that could differentiate adenoma from non-adenoma patients, and therefore, to prevent cancer progression. The impact of adenoma's endoscopic resection on microbiota was investigated, but the results were inconclusive. Further research in the field is required.

Keywords: Bacteroides; Fusobacteria; Proteobacteria; adenoma; colorectal cancer; endoscopy; gut; metabolomics; microbiota; polyp.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 2
Figure 2
Distribution of main bacterial families of human microbiota in the physiological condition and in adenoma patients (the thickness of the arrows is linked to the strength of the scientific evidence drawn from the literature).
Figure 1
Figure 1
Literature search flowchart diagram for systematic review.
See this image and copyright information in PMC

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