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Meta-Analysis
. 2021 Jun 1;13(6):1903.
doi: 10.3390/nu13061903.

Do Lifestyle Interventions in Pregnant Women with Overweight or Obesity Have an Effect on Neonatal Adiposity? A Systematic Review with Meta-Analysis

Naiara F Baroni  1 , Nayara R Baldoni  2   3 , Geisa C S Alves  2   4 , Lívia C Crivellenti  1 , Giordana C Braga  1 , Daniela S Sartorelli  5
Affiliations
Meta-Analysis

Do Lifestyle Interventions in Pregnant Women with Overweight or Obesity Have an Effect on Neonatal Adiposity? A Systematic Review with Meta-Analysis

Naiara F Baroni et al. Nutrients. .

Abstract

Excessive body fat at birth is a risk factor for the development of childhood obesity. The aim of the present systematic review with meta-analysis was to evaluate the effect of lifestyle interventions in pregnant women with overweight or obesity on neonatal adiposity. The PubMed, Embase, Web of Science, Scopus, and LILACS databases were used as information sources. Original articles from randomized clinical trials of lifestyle intervention studies on pregnant women with excessive body weight and the effect on neonatal adiposity were considered eligible. The risk of bias was assessed using Cochrane criteria. The meta-analysis was calculated using the inverse variance for continuous data expressed as mean difference (MD), using the random effect model with a 95% confidence interval (CI). The outcomes were submitted to the GRADE evaluation. Of 2877 studies, four were included in the qualitative and quantitative synthesis (n = 1494). All studies were conducted in developed countries, with three including pregnant women with overweight or obesity, and one only pregnant women with obesity. The interventions had no effect on neonatal adiposity [Heterogeneity = 56%, MD = -0.21, CI = (-0.92, 0.50)] with low confidence in the evidence, according to GRADE. Studies are needed in low- and medium-developed countries with different ethnic-racial populations. PROSPERO (CRD42020152489).

Keywords: adiposity; childhood obesity; intervention; lifestyle; newborn; pregnant women.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 flow diagram: identification and selection of studies process. BMI: body mass index.
Figure 2
Figure 2
Effect of the lifestyle interventions in pregnant women with excessive body weight on neonatal adiposity [38,39,40,41]. SD = standard deviation; CI = confidence interval; Tau2 = Tau-squared test; Chi2 = Chi-squared test; Df = difference; P = p value; I2 = heterogeneity; Z = Z test.
Figure 3
Figure 3
Effect of the lifestyle interventions in pregnant women with excessive body weight on neonatal adiposity according to the assessment method [38,39,40,41]. SD = standard deviation; CI = confidence interval; Tau2 = Tau-squared test; Chi2 = Chi-squared test; Df = difference; P = p value; I2 = heterogeneity; Z = Z test.
See this image and copyright information in PMC

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